Evidence map›Paper›PMID 40496729›Full record

ArticleMaterials today. Bio2025

Recent advances in NIR-II photothermal and photodynamic therapies for drug-resistant wound infections.

Xiang Chen, Zhanming Lin, Nuo Cheng, Yongjun Mo, Liang Lu, Jun Hou, Zhenghui Li, Xinyu Nie, Shuai Gao, Qikai Hua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  4. Potential of Nanoparticle-Based Phototherapies for Future Treatment of Uveal Melanoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. A biomimetic urchin-like photothermal nanoplatform for the efficient eradication ofFrontiers in cellular and infection microbiology · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiang ChenDepartment of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center/Research Centre for Regenerative Medicine), The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China.
Zhanming LinDepartment of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center/Research Centre for Regenerative Medicine), The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China.
Nuo ChengDepartment of Gastroenterology, Shanghai Fifth People's Hospital, Fudan University, 200240, Shanghai, China.
Yongjun MoDepartment of Orthopaedics, Guigang City People's Hospital, 537100, Guigang, China.
Liang LuDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230002, China.
Jun HouDepartment of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center/Research Centre for Regenerative Medicine), The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China.
Zhenghui LiDepartment of Neurosurgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Xinyu NieDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230002, China.
Shuai GaoHarvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Qikai HuaDepartment of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center/Research Centre for Regenerative Medicine), The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial infection can delay wound healing, while drug resistance further complicates the treatment of wound infection. Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is a non/mini-invasive and efficient antibacterial strategy that rarely induces bacterial resistance. This treatment relies on specific wavelengths of light to activate photothermal agents (PTAs) or photosensitizers, killing bacteria by generating local heats or reactive oxygen species (ROS), respectively. However, the light for traditional PTT/PDT mainly falls in the visible and near-infrared I light (Vis/NIR-I light, 400-900 nm) regions, which significantly limits further clinical translations due to its low tissue permeability. The near-infrared II (NIR-II,1000-1700 nm) light is increasingly utilized in antibacterial PTT/PDT to improve tissue penetration and ameliorate the immune microenvironment of deeper wounds. Meanwhile, NIR-II light offers a higher maximum permissible exposure (MPE) for PTT/PDT in treating wound infections, thereby facilitating the security, in comparison to Vis/NIR-I light. This review highlights recent advancements in NIR-II PTT/PDT for drug-resistant wound infections, focusing on mechanisms, therapeutic outcomes, challenges, and prospects.

Indexed as

Near-infrared IIPhotodynamic therapyPhotothermal therapyWound healingWound infections

Identifiers

PMID40496729
PMCPMC12148679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.