Evidence map›Paper›PMID 40496724›Full record

ArticleMaterials today. Bio2025

A thermosensitive hydrogel with synergistic stromal targeting and antitumor immunity modulation for pancreatic cancer immunotherapy.

Guozhi Zhao, Fan Guo, Wenhui Yan, Ying Qu, Chongzheng Yan, Huaiyou Lv, Genju Li, Jianxiong Zhao, Hanmiao Xie, Yizhe Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guozhi ZhaoDepartment of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan, Shandong Province, 250012, China.
Fan GuoDepartment of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan, Shandong Province, 250012, China.
Wenhui YanDepartment of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan, Shandong Province, 250012, China.
Ying QuDepartment of Pharmacy, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, 247 Beiyuan Street, Jinan, Shandong Province, 250012, China.
Chongzheng YanKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong Province, 250100, China.
Huaiyou LvYantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong Province, 264003, China.
Genju LiDepartment of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan, Shandong Province, 250012, China.
Jianxiong ZhaoDivision of Pancreatic Surgery, Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province, 250012, China.
Hanmiao XieShandong Research Center of Sports Science, Jinan, Shandong Province, 250102, China.
Yizhe LiDepartment of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan, Shandong Province, 250012, China.
Tingting TianDepartment of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan, Shandong Province, 250012, China.
Zhongxi ZhaoDepartment of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan, Shandong Province, 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is intrinsically characterized by an immunosuppressive microenvironment, in which the malignant extracellular matrix (ECM) creates a barrier that significantly impedes drug delivery, thereby undermining the overall anti-tumor immune responses. In this study, we present a novel thermosensitive hydrogel (SCC15+PLHCu@Gel) that co-deliver two types of nanoparticles loaded with the disulfiram derivative CPD12C15 (SCC15) and tumor-targeting Cu

Indexed as

Disulfiram derivative CPD12C15extracellular matrix targetingImmunity enhancementMicroenvironment remodelingPancreatic cancerThermosensitive hydrogel

Identifiers

PMID40496724
PMCPMC12150104

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.