Evidence map›Paper›PMID 40496722›Full record

ArticleMaterials today. Bio2025

Magnetically bioprinted anisotropic hydrogels promote BMSC osteogenic differentiation for bone defect repair.

Rong Xu, Hua Zhang, Yang Luo, Shiyi Pan, Chi Zhang, Xiaochuan Wu, Guofeng Zhang, Cuicui Su, Dongdong Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rong XuDepartment of Orthopedics, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China.
Hua ZhangResearch Institute of Smart Medicine and Biological Engineering, Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.
Yang LuoResearch Institute of Smart Medicine and Biological Engineering, Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.
Shiyi PanThe Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.
Chi ZhangDepartment of Orthopedics, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China.
Xiaochuan WuDepartment of Orthopedics, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China.
Guofeng ZhangDepartment of Orthopedics, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China.
Cuicui SuResearch Institute of Smart Medicine and Biological Engineering, Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, China.
Dongdong XiaDepartment of Orthopedics, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue engineering utilizing magnetic anisotropic hydrogels (MAHs) loaded with bone marrow-derived stem cells (BMSCs) offers a promising strategy to enhance the regeneration of bone defects due to their mechanotransduction and osteoinductive properties. However, the application of MAHs as bioinks for creating personalized 3D scaffolds faces significant challenges. Bioprinting necessitates a rapid sol-gel transition to enable the ink to form stable structures, whereas anisotropic shaping requires the ink to remain in a sol state post-printing, allowing magnetic particles to assemble freely under magnetic induction. To overcome these challenges, we develop a biomimetic MAH that recapitulate the anisotropic structures of the bone using a continuous Liquid-in-Liquid bioprinting method combined with magnetic induction. The constructed MAHs feature uniformly aligned Fe

Indexed as

Anisotropic hydrogelBioprintingBone repairOsteogenic differentiation

Identifiers

PMID40496722
PMCPMC12149643

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.