ArticleBioactive materials2025
The multifaceted biomimetic titanium implant promotes bone integration with sequential antibacterial and immune modulation properties.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Defect-Mediated Sonodynamic Catalysis on Calcium-Deficient Hydroxyapatite Nanoparticles Coordinating Bacterial Elimination and Bone Regeneration against Osteomyelitis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Silk Fibroin-Modified Titanium Implants for Bone Tissue Engineering: Structural Basis, Functionalization and Composite Strategies.Macromolecular bioscience · 2026Review
- Injectable Composite Hydrogels Orchestrating Macrophage Reprogramming and Chondrogenesis to Promote Microfracture-Assisted Cartilage Repair.Advanced healthcare materials · 2026Article
- Periprosthetic Joint Infection: Biofilm Pathogenesis, Immune Dysregulation, and Emerging Prosthetic Interface Strategies.Biology · 2026Review
- Article
- Non-destructive debridement and tuneable ion release via magnesium abrasion and electro-dissolution promote bone regeneration and osseointegration of infected implants.Materials today. Bio · 2026Article
- Polydopamine-assisted lithium ion loading on titanium alloy synergistically enhances osteogenesis and immunomodulation for bone regeneration: an In Vitro study.BMC oral health · 2026Article
- Nanomaterial-based strategies for oral biofilm management: functionalized implants and targeted delivery systems.Frontiers in oral health · 2026Review
- Regulation of bone immunity by metal ions: a review of mechanisms and application progress.Frontiers in immunology · 2026Review
- Beyond bioactivity: Chitosan macromolecular coatings on titanium surfaces drive osseointegration and immune suppression through targeted epigenetic regulation.Iranian journal of basic medical sciences · 2026Article
- The Sr-HA-loaded PLGA cage structure combines cells to construct a bone tissue repair unit.Regenerative biomaterials · 2026Article
- Intelligent response hydrogel based on choline phosphorylated chitosan programmed repair of infected wounds.Regenerative biomaterials · 2026Article
- Therapeutic Metal Ions: Engineering Biomaterials for Multimodal Disease Treatment.International journal of nanomedicine · 2026Review
- Manganese-doped nano-hydroxyapatite enhances CF/PEEK osseointegration via immunomodulation-osteogenesis coupling.Regenerative biomaterials · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium (Ti) and its alloy implants often face issues such as insufficient tissue adhesion and vulnerability of the bio inert surface. Given that the long-term stability of implants depends on their perfect integration with the surrounding tissues to withstand various environmental stresses, current research mainly focuses on mimicking the structure of the extracellular matrix. The aim is to promote bone tissue formation through regulation of the immune response by metal ions, thereby enhancing the effectiveness of tissue integration. The self-assembled zinc (Zn)-doped hydroxyapatite nanoparticles (nHA) with polydopamine (PDA) and copper ions (Cu
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