Evidence map›Paper›PMID 40496622›Full record

ReviewFrontiers in oncology2025

Surgical management of head and neck squamous cell carcinoma metastatic to the parotid gland.

Michał Gontarz, Marta Urbańska, Jakub Bargiel, Krzysztof Gąsiorowski, Tomasz Marecik, Grażyna Wyszyńska-Pawelec

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michał GontarzDepartment of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, University Hospital, Cracow, Poland.
Marta UrbańskaAmethyst Radiotherapy Centre, Cracow, Poland.
Jakub BargielDepartment of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, University Hospital, Cracow, Poland.
Krzysztof GąsiorowskiDepartment of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, University Hospital, Cracow, Poland.
Tomasz MarecikDepartment of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, University Hospital, Cracow, Poland.
Grażyna Wyszyńska-PawelecDepartment of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, University Hospital, Cracow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The parotid gland includes lymph nodes that may contain metastasis from the head and neck region as well as distant metastasis or metastasis from carcinoma/melanoma of an unknown primary (CUP/MUP). This study aimed to review the current literature to evaluate the role of surgical management of head and neck squamous cell carcinoma (HNSCC). A narrative review of the English language literature available in the PubMed and Embase databases from January 2010 to December 2024 was conducted to identify treatment methods and follow-up data for HNSCC metastatic to the parotid gland. This study provides a detailed overview of the histological and diagnostic imaging characteristics as well as the surgical and non-surgical procedures employed in the management of HNSCC metastases to the parotid gland. Furthermore, the management of CUP is outlined. The extent of the parotidectomy and concomitant neck dissection remains a topic of ongoing debate. The flow chart presented in this study may assist in decision-making regarding surgical treatment. Given that locoregional recurrence is the primary cause of mortality in HNSCC, surgical treatment is likely to be the most effective means of achieving a favorable outcome.

Indexed as

carcinoma of unknown primarycutaneous squamous cell carcinomaelective parotidectomyhead and neck squamous cell carcinomaparotid metastasissecondary tumor

Identifiers

PMID40496622
PMCPMC12149202

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.