Evidence map›Paper›PMID 40496595›Full record

ArticleOrthopaedic journal of sports medicine2025

Vascularization Characteristics of the Different Meniscal Layers: Three-Dimensional Assessment With Micro-CT.

Federica Orellana, Stefano Zaffagnini, Ruslan Hlushchuk, Oleksiy-Zakhar Khoma, Sébastien Halm, Annapaola Parrilli, Alberto Grassi

Abstract read
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Article in Orthopaedic journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The ageing meniscus: Pathophysiology, epidemiology and management.Journal of experimental orthopaedics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Federica OrellanaEmpa-Swiss Federal Laboratories for Materials Science and Technology, Center for X-ray Analytics, Dübendorf, Switzerland.
Stefano ZaffagniniIRCCS-Rizzoli Orthopaedic Institute, 2nd Orthopaedic and Traumatologic Clinic, Bologna, Italy.
Ruslan HlushchukUniversity of Bern, Institute of Anatomy, Bern, Switzerland.
Oleksiy-Zakhar KhomaUniversity of Bern, Institute of Anatomy, Bern, Switzerland.
Sébastien HalmUniversity of Bern, Institute of Anatomy, Bern, Switzerland.
Annapaola ParrilliEmpa-Swiss Federal Laboratories for Materials Science and Technology, Center for X-ray Analytics, Dübendorf, Switzerland.ORCID https://orcid.org/0000-0003-0251-5094
Alberto GrassiIRCCS-Rizzoli Orthopaedic Institute, 2nd Orthopaedic and Traumatologic Clinic, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Degenerative meniscal lesions are often characterized by horizontal cleavage tears, and there is currently no established gold standard for treating these injuries. Understanding the vascularization and distribution of blood vessels along the meniscal layers could offer valuable insights into the management and healing of these tears. Hypothesis: Distinct vascularization patterns could be identified in different layers of the meniscus along the proximal-distal axis, providing new insights and potentially expanding or refining existing classification systems. Study Design: Descriptive laboratory study. Methods: To visualize the meniscal microvasculature, human cadaveric legs were perfused with a polymer-based contrast agent, followed by micro-computed tomography imaging. The menisci were virtually divided into transverse (layers), radial (thirds), and circumferential zones to quantify the vascular contribution of each zone and to evaluate vascular parameters such as segment diameter, tortuosity, and the number of vessel segments. Results: In the medial meniscus, the inferior surface of the outermost zone and the intermediate layers of the peripheral zones showed a potential reduction in vessel percentage. In the lateral meniscus, a relatively higher percentage of vessels was observed from the superficial to the inferior layers of the posterior horn, extending into the inner zones. Additionally, the lateral meniscus exhibited a greater number of vessels with smaller diameters compared with the medial meniscus. Conclusion: This micro-computed tomography approach for analyzing spatial vascular distribution offers a more comprehensive view of meniscal vasculature across multiple planes and regions. Clinical Relevance: This study may pave the way for new classifications that identify highly and poorly vascularized regions of the meniscus, potentially improving the effectiveness of treatments for meniscal injuries, ultimately reducing recovery time and improving long-term joint health for patients.

Indexed as

3D imagingmeniscal tearsmeniscal vascular networkmeniscusmicro-CT

Identifiers

PMID40496595
PMCPMC12149635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.