Evidence map›Paper›PMID 40496581›Full record

ArticleHeart rhythm O22025

Vein of Marshall ethanol infusion improves ablation outcomes in patients with persistent atrial fibrillation.

Mohammed Al-Sadawi, Rushil N Shah, Amrish Deshmukh, Jackson J Liang, Krit Jongnarangsin, Fred Morady, Hakan Oral, Aman Chugh, Michael Ghannam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed Al-SadawiDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Rushil N ShahDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Amrish DeshmukhDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Jackson J LiangDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Krit JongnarangsinDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Fred MoradyDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Hakan OralDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Aman ChughDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.
Michael GhannamDivision of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vein of Marshall ethanol infusion (VoMEI) may improve outcomes among patients with persistent atrial fibrillation (AF) undergoing catheter ablation procedures. Prior investigations used heterogeneous ablation strategies, limiting the understanding of VoMEI utility. Objective: The study sought to examine the safety and efficacy of a uniform ablation approach utilizing VoMEI compared with patients undergoing pulmonary vein isolation (PVI) only or PVI and posterior wall isolation (PWI). Methods: Patients undergoing first-time ablation for persistent AF utilizing VoMEI with PVI, PWI, and ablation of induced macro-re-entry arrhythmias were included. Two propensity-matched control groups (PVI only and PVI + PWI) were identified with 2:1 matching. Safety and efficacy rates between the groups were examined. Results: A total of 155 patients were included (VoMEI, n = 31; PVI, n = 62; PVI + PWI, n = 62), consisting of 98 (63%) males 66 ± 10 years of age, with left atrial diameter 49 ± 7 mm, ejection fraction 50 ± 16%, and follow-up time 3.2 ± 2.2 years, with no demographic differences between the groups ( Conclusion: Among patients with persistent AF, an ablation strategy incorporating VoMEI improved long-term ablation outcomes compared with groups of propensity-matched patients undergoing PVI only or PVI + PWI.

Indexed as

Catheter ablationEthanol ablationNonparoxysmal atrial fibrillationPosterior wall ablationVein of Marshall

Identifiers

PMID40496581
PMCPMC12147582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.