Evidence map›Paper›PMID 40496497›Full record

ArticleChemical science2025

Mass spectrometric imaging of organic and metallic metabolites by plasmon-induced interfacial charge-transfer transition (PICTT) on Au sputtered ITO slides.

Shao Chang, Xin Zhou, Anji Gao, Yixiang Luo, Yujia Shan, Lin Zhang, Zhengwei Gui, Xingchen Huang, Xiaoyuan Hu, Tianci Huo and 2 more

Abstract read
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Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Shao ChangState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, College of Life Science and Technology, Medical College of Guangxi University, Center for Instrumental Analysis, Guangxi University Nanning Guangxi 530004 P. R. China hyzhong@gxu.edu.cn.
Xin ZhouState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, College of Life Science and Technology, Medical College of Guangxi University, Center for Instrumental Analysis, Guangxi University Nanning Guangxi 530004 P. R. China hyzhong@gxu.edu.cn.
Anji GaoInnovation Academy for Precision Measurement Science and Technology, Chinese Academy of Science Wuhan 430071 P. R. China.
Yixiang LuoState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, College of Life Science and Technology, Medical College of Guangxi University, Center for Instrumental Analysis, Guangxi University Nanning Guangxi 530004 P. R. China hyzhong@gxu.edu.cn.
Yujia ShanSchool of Computer Science, National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University Wuhan Hubei 430079 P. R. China.
Lin ZhangTongji Medical College, Huazhong University of Science and Technology Wuhan Hubei 430030 P. R. China.
Zhengwei GuiTongji Medical College, Huazhong University of Science and Technology Wuhan Hubei 430030 P. R. China.
Xingchen HuangState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, College of Life Science and Technology, Medical College of Guangxi University, Center for Instrumental Analysis, Guangxi University Nanning Guangxi 530004 P. R. China hyzhong@gxu.edu.cn.
Xiaoyuan HuState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, College of Life Science and Technology, Medical College of Guangxi University, Center for Instrumental Analysis, Guangxi University Nanning Guangxi 530004 P. R. China hyzhong@gxu.edu.cn.
Tianci HuoState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, College of Life Science and Technology, Medical College of Guangxi University, Center for Instrumental Analysis, Guangxi University Nanning Guangxi 530004 P. R. China hyzhong@gxu.edu.cn.
Linhui LiuSchool of Computer Science, National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University Wuhan Hubei 430079 P. R. China.
Hongying ZhongState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, College of Life Science and Technology, Medical College of Guangxi University, Center for Instrumental Analysis, Guangxi University Nanning Guangxi 530004 P. R. China hyzhong@gxu.edu.cn.ORCID https://orcid.org/0000-0003-2733-7909

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protonation/deprotonation is the major ionization mechanism of organic molecules in current electrospray ionization (ESI) and matrix assisted laser desorption ionization mass spectrometric (MALDI MS) imaging. But cellular complexities are far beyond protonated or deprotonated organic molecules. There are tremendous endogenous organic and metallic metabolites regulating oxidation-reduction homeostasis that cannot be protonated or deprotonated. We describe an electron-driven ionization paradigm for mass spectrometric imaging of organic and metallic metabolites based on the charge and energy flow at the plasmonic metal-molecule interface. Enhanced plasmonic electron transfer was observed on Au sputtered ITO glass slides that were made with a physical vapor deposition approach. Plasmon-induced interfacial charge-transfer transition (PICTT) enables the decay of plasmons by direct excitation of electrons from Au atoms to strongly coupled electron receptors in tissue sections that are blotted on Au sputtered ITO slides. The highly reactive plasmonic hot electrons facilitate not only the mass spectrometric imaging of endogenous organic metabolites but also the

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PMID40496497
PMCPMC12146782

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