Evidence map›Paper›PMID 40496475›Full record

ArticleOncology letters2025

Single‑cell transcriptomic analysis revealed the tumor‑associated microenvironment of papillary thyroid carcinoma with metastasis.

Ni Zhang, Qingbin Liu, Qian Wang, Xiuli Liu, Suya Zhang, Xinchen Tian, Long Li, Shuanglong Wang, Bin Lv, Shulong Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ni ZhangCheeloo College of Medicine, Shandong University, Jinan, Shandong 250000, P.R. China.
Qingbin LiuClinical Medical Laboratory Center, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Qian WangDepartment of Ultrasonic Medicine, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Xiuli LiuDepartment of Breast and Thyroid Surgery, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Suya ZhangDepartment of Ultrasonic Medicine, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Xinchen TianClinical Medical Laboratory Center, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Long LiDepartment of Ultrasonic Medicine, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Shuanglong WangDepartment of Ultrasonic Medicine, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Bin LvDepartment of Ultrasonic Medicine, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong 272000, P.R. China.
Shulong JiangCheeloo College of Medicine, Shandong University, Jinan, Shandong 250000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillary thyroid cancer (PTC) is frequently associated with inflammation and lymph node metastasis. Single-cell RNA sequencing (scRNA-seq) is a powerful tool to uncover rare cellular subpopulations and investigate the diverse functions inside tissue microenvironments. In the present study, scRNA-seq analysis was employed to analyze the differences in macrophages, dendritic cells (DCs) and T cells between a metastatic PTC (PTC-M) and its adjacent normal tissues, as well as a PTC tumor without metastasis. The findings revealed significant heterogeneity in immune cell populations in PTC-M, suggesting that immunosuppressive components contribute to the development and metastasis of PTC. The current study revealed that the presence of alternatively activated M2 macrophages, conventional type 2 DCs (DC2s) and regulatory T cells (Tregs) was associated with increased lymph node metastasis and a more advanced stage of cancer. On the other hand, monocytes and B cells may have a beneficial effect in fighting against tumors. A group of tumor-associated DC2s expressing both

Indexed as

dendritic cellmicroenvironmentpapillary thyroid cancersingle-cell RNA sequencing

Identifiers

PMID40496475
PMCPMC12149705

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.