Evidence map›Paper›PMID 40496375›Full record

ArticleRSC advances2025

Impact of trifluoromethyl Ugi adducts as anticancer agents: EGFR inhibition, apoptosis induction and miRNA up-regulation.

Mohammed Salah Ayoup, Eman Mamdouh, Saied M Soliman, Ibrahim Elghamry, Mohamed S Nafie, Amr Negm, Amr Sonousi, Asmaa E Kassab, Laila F Awad

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed Salah AyoupDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia mayoup@kfu.edu.sa mohammedsalahayoup@gmail.com.ORCID https://orcid.org/0000-0001-6715-5478
Eman MamdouhChemistry Department, Faculty of Science, Alexandria University P. O. Box 426 Alexandria 21321 Egypt laila.fathy@yahoo.com.
Saied M SolimanChemistry Department, Faculty of Science, Alexandria University P. O. Box 426 Alexandria 21321 Egypt laila.fathy@yahoo.com.ORCID https://orcid.org/0000-0001-8405-8370
Ibrahim ElghamryDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia mayoup@kfu.edu.sa mohammedsalahayoup@gmail.com.
Mohamed S NafieDepartment of Chemistry, College of Sciences, University of Sharjah Sharjah 27272 United Arab Emirates.ORCID https://orcid.org/0000-0003-4454-6390
Amr NegmDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia mayoup@kfu.edu.sa mohammedsalahayoup@gmail.com.ORCID https://orcid.org/0000-0001-9801-3261
Amr SonousiDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street, P. O. Box 11562 Cairo Egypt.ORCID https://orcid.org/0000-0002-7111-8837
Asmaa E KassabDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street, P. O. Box 11562 Cairo Egypt.ORCID https://orcid.org/0000-0002-6091-829X
Laila F AwadChemistry Department, Faculty of Science, Alexandria University P. O. Box 426 Alexandria 21321 Egypt laila.fathy@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel bis-amide Ugi adducts with a Y-shaped configuration imitating the thematic feature of fourth-generation EGFR inhibitors was designed and synthesized

Identifiers

PMID40496375
PMCPMC12150293

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.