Evidence map›Paper›PMID 40496335›Full record

ArticleACS electrochemistry2025

Sensitive Imaging of Electroactive Species in Plasmonic Electrochemical Microscopy Enabled by Nanoconfinement.

Samuel Groysman, Yisi Chen, Adaly Garcia, Christian Martinez, Kevin Diego-Perez, Miriam Benavides, Yi Chen, Zijian Wan, Shaopeng Wang, Rujia Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS electrochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samuel GroysmanDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.ORCID https://orcid.org/0009-0006-5008-6772
Yisi ChenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Adaly GarciaDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Christian MartinezDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Kevin Diego-PerezDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Miriam BenavidesDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Yi ChenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID https://orcid.org/0000-0002-6660-5198
Zijian WanBiodesign Center for Biosensors and Bioelectronics, Arizona State University, Tempe, Arizona 85281, United States.ORCID https://orcid.org/0000-0001-7923-6451
Shaopeng WangBiodesign Center for Biosensors and Bioelectronics, Arizona State University, Tempe, Arizona 85281, United States.ORCID https://orcid.org/0000-0002-2680-0503
Rujia LiuSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Dengchao WangSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.ORCID https://orcid.org/0000-0002-4909-7830
Chong LiuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID https://orcid.org/0000-0001-5546-3852
Yixian WangDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.ORCID https://orcid.org/0000-0001-8691-1128

Funding

Undergraduate Research Training for Student Enhancement (U-RISE) at Cal State LAT34GM145503 · NIGMS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI KRISHNA L FOSTER · 2022 to 2026
$3.7M
Spatiotemporal control of concentration gradients with electrochemistry in extracelluar spaceR35GM138241 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Chong Liu · 2020 to 2026
$2.8M
Optical imaging of size, charge, mobility and binding of single proteinsR01GM140193 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, SHAOPENG · 2022 to 2025
$1.2M
NIGMS NIH HHS R01 GM140193NIGMS NIH HHS R35 GM138241NIGMS NIH HHS T34 GM145503
6 · The paper itself

Abstract

Spatially resolved sensing is a burgeoning area of electrochemistry that, in contrast to traditional electrochemical techniques, allows for the analysis of heterogeneous systems such as neurotransmitter release from cells. Of these techniques, optical microscopy methods are valued for real-time high throughput sensing. However, improving the sensitivity of many optical techniques remains a challenge. Here, we modify the gold (Au) electrode of the standard plasmonic electrochemical microscopy (PEM) setup with a mesoporous silica film (MSF) to achieve sensitive imaging of the electroactive species. Sensitivity enhancement occurs via species nanoconfinement from the attraction of ions to the negatively charged silica films, thereby increasing the local concentration change and magnifying the PEM signal. The performance of Au-MSF electrodes in the PEM setup was investigated using 1,1'-ferrocenedimethanol, whose oxidized form carries a positive charge. Results revealed enhancement of the sensing signal, with up to 37-fold improvement in the detection limit and up to 23 times improvement in the sensitivity. Importantly, Au-MSF electrodes allowed for the quantification of detected concentrations, in contrast to Au electrodes, for which R

Indexed as

dopamine detectionelectrochemistryMesoporous silica filmsnumerical simulationsurface plasmon resonance imaging

Identifiers

PMID40496335
PMCPMC12147111

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.