ArticleACS electrochemistry2025
Determination of Enantiomeric Excess in Confined Aprotic Solvent.
Article in ACS electrochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The validation of the stereochemical purity of synthesized compounds is a requisite for the fine-chemical industry, particularly in the production of enantiopure drug compounds. However, most methodologies employed in the determination of enantiopurity require carefully chosen chiral GC or HPLC columns, increasing associated cost, analysis time, and complexity. Herein, we present a nanopore-based technology for the determination of enantiopurity, exploiting changes in ion-current rectification of quartz nanopipettes containing an aprotic organic electrolyte. Changes in solvent ordering at the quartz surface upon enantiomerically preferential adsorption give rise to distinguishable current-voltage responses. The applicability of our simple and cost-effective platform is demonstrated through the determination of the enantiomeric excess of commercially available (
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