ArticleWorld journal of orthopedics2025
Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review.
Article in World journal of orthopedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Use of Fibrin Sealant Combined With Demineralized Freeze-Dried Bone Allograft in the Management of a Recurrent Mandibular Aneurysmal Bone Cyst: A Case Report.Clinical case reports · 2026Article
- Tetracalcium Phosphate Graft for Implant Stabilization: Resonance Frequency and Histomorphometric Analysis in a Sheep Tibia Model.Journal of functional biomaterials · 2026Article
- Bone-Healing Enhancement Using Particulate Biomaterials and Fibrin-Based Compounds: A Narrative Literature Review of Evidence in Animal Models.Materials (Basel, Switzerland) · 2026Review
- Hydroxyapatite-based bone repair biomaterials based on clinical heterogeneity: modification strategies, performance regulation, and personalized repair pathways.Frontiers in bioengineering and biotechnology · 2026Review
- Biodegradable materials: Applications and advances of magnesium alloys in bone defects.World journal of orthopedics · 2025Article
- Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives.World journal of orthopedics · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone regeneration is a central focus of regenerative medicine, with applications in orthopedics and dentistry, particularly for treating bone defects caused by trauma, infection, or congenital anomalies. Synthetic biomaterials, often combined with fibrin derivatives, offer promising solutions for bone healing and restoration.
aimTo Explore the increasingly important role of the association of synthetic biomaterials with fibrin in bone regeneration.
methodsSearch terms included: "synthetic biomaterials AND fibrin sealant", "hydroxyapatite AND fibrin sealant", "tricalcium phosphate AND fibrin sealant", and "synthetic biomaterials AND platelet-rich fibrin (PRF)", resulting in 67 articles. After rigorous screening, 21 articles met the inclusion criteria.
resultsThe reviewed studies assessed biomaterials like hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and fibrin-based products. Key findings highlighted the enhanced osteoconductivity and biocompatibility of HA and β-TCP, especially when combined with fibrin sealants. These composites show significant potential for improving cellular adhesion, promoting osteogenic differentiation, and accelerating bone regeneration. The antimicrobial properties and structural support for cell growth of certain biomaterials indicate a promising potential for clinical applications.
conclusionThis systematic review emphasizes the growing role of fibrin-based biomaterials in bone regeneration and urges continued research to improve their clinical use for complex bone defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.