ArticleWorld journal of orthopedics2025
Role of neutrophil to lymphocyte ratio in osteoarthritis: A systematic review and meta-analysis.
Article in World journal of orthopedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden.Journal of clinical medicine · 2026Article
- Metabolic-inflammatory phenotypes, osteoarthritis, and lower-extremity functional limitation in US adults: a NHANES 2007-2018 study.Clinical rheumatology · 2026Article
- Syndecan-2 Regulates Integrin-β1 to Influence the Abnormal Subchondral Bone in Early-stage Knee Osteoarthritis.Applied biochemistry and biotechnology · 2026Article
- The Platelet-Rich Plasma research ecosystem: From mechanistic insights to precision treatment in knee osteoarthritis.Regenerative therapy · 2025Review
- Systemic Inflammation in Hip Fracture and Osteoarthritis: Insights into Pathways of Immunoporosis.International journal of molecular sciences · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundOsteoarthritis (OA) involves low-grade inflammation. The neutrophil-to-lymphocyte ratio (NLR) may serve as a simple biomarker, but its role in OA remains unclear.
aimTo review the existing scientific literature on the role of NLR in OA, a classic age-related disorder, to perform a meta-analysis of the available data.
methodsThe electronic databases PubMed, ProQuest, and Scopus were systematically searched from inception to March 1, 2024. The inclusion criteria were retrospective and prospective case-control studies involving human subjects with OA and healthy controls. The included studies needed to provide NLR levels for both OA patients and healthy controls and perform a comparative analysis of NLR levels between these groups.
resultsAccording to the PRISMA guidelines, fifteen articles were included in the meta-analysis after multiple screenings. The pooled results demonstrated a significant overall elevation of NLR in OA patients compared to healthy controls. (standardized mean difference = 0.39, 95% confidence interval: 0.03-0.75,
conclusionOur study found that OA patients have higher NLR than healthy individuals. However, NLR did not significantly differ by study type or disease severity, suggesting its limited use in indicating OA severity.
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