Evidence map›Paper›PMID 40496187›Full record

ArticlePNAS nexus2025

Mitochondrial PTRH2 controls the deubiquitinase TRABID to regulate mt-ND5 stability and metabolism.

Carlotta Giorgi, Femke J Aan, Natalija Glibetic, Daniela Ramaccini, Lorenzo Modesti, Veronica A M Vitto, Vanessa Montoya-Uribe, Austin Corpuz, Sonia Missiroli, Inês Simões and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carlotta GiorgiDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.ORCID https://orcid.org/0000-0002-2494-7405
Femke J AanDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID https://orcid.org/0009-0006-7885-6118
Natalija GlibeticDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Daniela RamacciniDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
Lorenzo ModestiDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.ORCID https://orcid.org/0000-0001-8206-6625
Veronica A M VittoDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.ORCID https://orcid.org/0000-0002-7189-350X
Vanessa Montoya-UribeDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Austin CorpuzUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
Sonia MissiroliDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.ORCID https://orcid.org/0000-0003-4530-617X
Inês SimõesLaboratory of Mitochondrial Biology and Metabolism, Department of Biochemistry, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw 02-093, Poland.
Yaiza PotesLaboratory of Mitochondrial Biology and Metabolism, Department of Biochemistry, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw 02-093, Poland.ORCID https://orcid.org/0000-0002-4687-6230
Mariusz R WieckowskiLaboratory of Mitochondrial Biology and Metabolism, Department of Biochemistry, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw 02-093, Poland.ORCID https://orcid.org/0000-0003-0789-4521
Joe W RamosLouisiana Cancer Research Center, Cancer Biology, New Orleans, LA 70112, USA.
Paolo PintonDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
Michelle L MatterDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID https://orcid.org/0000-0002-5988-9663

Funding

Translational Genomics Core (TGC)P20GM121288 · NIGMS · LSU HEALTH SCIENCES CENTER · PI Arunava Roy · 2017 to 2026
$22.4M
Protecting the Maternal Heart From Pregnancy-Associated Heart DiseaseR01HD091162 · NICHD · UNIVERSITY OF HAWAII AT MANOA · PI MATTER, MICHELLE L · 2018 to 2022
$1.9M
NICHD NIH HHS R01 HD091162NIGMS NIH HHS P20 GM121288
6 · The paper itself

Abstract

The integrin effector, PTRH2, associates with mitochondria in adherent cells where its function has not been elucidated (Jan Y,

Indexed as

metabolismmitochondrial Ca2+ overloadmt-ND5PTRH2TRABID

Identifiers

PMID40496187
PMCPMC12150287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.