Evidence map›Paper›PMID 40496178›Full record

ArticleUrology case reports2025

Unilateral pubic hair growth: a paracrine finding indicative of underlying leydig cell tumor in a prepubertal boy.

Gabriel van de Walle, Luca A Morgantini, Bronwyn G Long, Nicoleta C Arva, Cristiana Hentea, Claudia C Boucher Berry, Amanda Osta, Emilie K Johnson

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriel van de WalleAnn & Robert H. Lurie Children's Hospital of Chicago, Division of Urology, Chicago, IL, USA.
Luca A MorgantiniAnn & Robert H. Lurie Children's Hospital of Chicago, Division of Urology, Chicago, IL, USA.
Bronwyn G LongAnn & Robert H. Lurie Children's Hospital of Chicago, Division of Urology, Chicago, IL, USA.
Nicoleta C ArvaNationwide Children's Hospital, Department of Pathology and Laboratory Medicine, Columbus, OH, USA.
Cristiana HenteaUniversity of Illinois at Chicago, Division of Pediatric Hematology/Oncology, Chicago, IL, USA.
Claudia C Boucher BerryUniversity of Illinois at Chicago, Division of Pediatric Endocrinology, Chicago, IL, USA.
Amanda OstaUniversity of Illinois at Chicago, Department of Pediatrics, Chicago, IL, USA.
Emilie K JohnsonAnn & Robert H. Lurie Children's Hospital of Chicago, Division of Urology, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leydig cell tumors (LCTs) are rare in children and typically present with testicular masses and signs of early puberty. We report a case of a 6-year-old boy presenting solely with precocious pubic hair growth. Ultrasound revealed a small right testicular mass and elevated serum testosterone. Intra-operatively, hair growth was more prominent on the affected hemi-scrotum. Testis-sparing surgery confirmed a benign LCT with adjacent increased spermatogenesis. This is the first known report of ipsilateral pubic hair as a presenting sign of LCT. Localized androgen excess may be an early clinical indicator to guide timely diagnosis and treatment.

Indexed as

Leydig cell tumorParacrine effectsPrecocious pubertyPubic hairSex cord-gonadal stromal tumorTestis massTestis neoplasmTestis-sparing surgery

Identifiers

PMID40496178
PMCPMC12148672

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.