Evidence map›Paper›PMID 40496145›Full record

ArticleThe Lancet regional health. Southeast Asia2025

Neuromelioidosis outbreak in Tamil Nadu, India: an investigation of transmission with genomic insights.

Angel Miraclin Thirugnanakumar, Prabu Rajkumar, Karthik Gunasekaran, Pavithra Mannam, Manickam Ponnaiah, Girish Kumar Chethrapilly Purushothaman, Aravind Velmurugan, Ayyan Raj Neeravi, Jobin John Jacob, Solomon D Cruz and 36 more

Abstract read
In one paragraph

Article in The Lancet regional health. Southeast Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Methodological issue in a dental neuromelioidosis outbreak investigation.The Lancet regional health. Southeast Asia · 2025
    Article
  6. BimAIJID regions · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Angel Miraclin ThirugnanakumarDepartment of Neurological Sciences (Division of Neurology), Christian Medical College, Vellore, Tamil Nadu, India.
Prabu RajkumarIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Karthik GunasekaranDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Pavithra MannamDepartment of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India.
Manickam PonnaiahIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Girish Kumar Chethrapilly PurushothamanIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Aravind VelmuruganDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Ayyan Raj NeeraviDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Jobin John JacobDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Solomon D CruzDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Bhagteshwar SinghLiverpool School of Tropical Medicine, United Kingdom.
Prabhakar Appaswamy ThirumalDepartment of Neurological Sciences (Division of Neurology), Christian Medical College, Vellore, Tamil Nadu, India.
Anitha JasperDepartment of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India.
Malu MohanIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Devika ShanmugasundaramIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Ananth AbrahamDepartment of Neurological Sciences (Division of Neurosurgery), Christian Medical College, Vellore, Tamil Nadu, India.
Senthil ThangarajanDirectorate of Public Health and Preventive Medicine, Tamil Nadu, India.
Tony PanickerDepartment of Neurological Sciences (Division of Neurosurgery), Christian Medical College, Vellore, Tamil Nadu, India.
Bijesh NairDepartment of Neurological Sciences (Division of Neurosurgery), Christian Medical College, Vellore, Tamil Nadu, India.
Aravintharaj SelvakumarDirectorate of Public Health and Preventive Medicine, Tamil Nadu, India.
Ranjith K MoorthyDepartment of Neurological Sciences (Division of Neurosurgery), Christian Medical College, Vellore, Tamil Nadu, India.
Baylis Vivek JosephDepartment of Neurological Sciences (Division of Neurosurgery), Christian Medical College, Vellore, Tamil Nadu, India.
Krishna PrabhuDepartment of Neurological Sciences (Division of Neurosurgery), Christian Medical College, Vellore, Tamil Nadu, India.
Devarajulu Reddy SirasanambatiIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Shalini NairDepartment of Critical Care Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Murali UmapathyIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Kishore PitchamuthuDepartment of Critical Care Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Balusamy MurugesanIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Sowmya SathyendraDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Samuel George HansdakDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Hema PaulDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Rajesh IsaiahDepartment of Radiation Oncology, Christian Medical College, Vellore, Tamil Nadu, India.
Kundavaram Paul P AbhilashDepartment of Emergency Medicine, Christian Medical College, Vellore, India.
Aditya V NairDepartment of Neurological Sciences (Division of Neurology), Christian Medical College, Vellore, Tamil Nadu, India.
Vivek MathewDepartment of Neurological Sciences (Division of Neurology), Christian Medical College, Vellore, Tamil Nadu, India.
Ajith SivadasanDepartment of Neurological Sciences (Division of Neurology), Christian Medical College, Vellore, Tamil Nadu, India.
Maya Mary ThomasDepartment of Neurological Sciences (Division of Pediatric Neurology), Christian Medical College, Vellore, Tamil Nadu, India.
Sanjith AaronDepartment of Neurological Sciences (Division of Neurology), Christian Medical College, Vellore, Tamil Nadu, India.
John Antony Jude PrakashDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Geeta ChackoDepartment of General Pathology (Division of Neuropathology), Christian Medical College, Vellore, Tamil Nadu, India.
Priscilla RupaliDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
Tom SolomonLiverpool School of Tropical Medicine, United Kingdom.
Somasundaram AnavarathanDirectorate of Public Health and Preventive Medicine, Tamil Nadu, India.
Selvavinayagam Thirumalaichiry SivaprakasamDirectorate of Public Health and Preventive Medicine, Tamil Nadu, India.
Balaji VeeraraghavanDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Manoj MurhekarIndian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In May 2023, we investigated a cluster of neuromelioidosis notified from Tamil Nadu state in southern India to describe case characteristics and identify the infection source. Methods: We searched for probable cases presenting with fever and brainstem syndrome, supported by radiological findings suggestive of neuromelioidosis. Cases were confirmed by isolation of Findings: We identified 21 probable cases between July 2022 and April 2023 (median age = 33 years; 11 females; five confirmed) across four districts in Northern Tamil Nadu. Seventeen cases were from a single district and 10 reported prior dental treatment at a clinic. Cases with dental exposure had higher fatality (8/10 vs. 1/11) and shorter time to death (median 17 days vs. 1 death at day 56) than sporadic cases. The Interpretation: We confirmed a large cluster of neuromelioidosis from South India, likely representing sporadic cases from environmental sources and cases linked to an iatrogenic source at a dental clinic. Rapid and high case fatality among dental cases supports the direct trans-neural spread of Funding: None.

Indexed as

Burkholderia mallei–like bimABm geneBurkholderia pseudomalleiDental proceduresNeuromelioidosisNeuro virulenceOutbreakSouth India

Identifiers

PMID40496145
PMCPMC12149414

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