Evidence map›Paper›PMID 40496124›Full record

ReviewFrontiers in neurology2025

RT-QuIC: a highly promising diagnostic method for neurodegenerative diseases-advantages and limitations.

D Koníčková, D Hraboš, K Menšíková, L Tučková, M Kaleta, M Strnad, C Colosimo, P Kaňovský

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

D KoníčkováDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czechia.
D HrabošDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czechia.
K MenšíkováDepartment of Neurology, University Hospital Olomouc, Olomouc, Czechia.
L TučkováDepartment of Neurology, University Hospital Olomouc, Olomouc, Czechia.
M KaletaDepartment of Neurology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czechia.
M StrnadDepartment of Neurology, University Hospital Olomouc, Olomouc, Czechia.
C ColosimoDepartment of Neurology, Santa Maria University Hospital, Terni, Italy.
P KaňovskýDepartment of Neurology, University Hospital Olomouc, Olomouc, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although it has been more than 200 years since Parkinson's disease was described, we have not established biomarkers for its definitive diagnosis yet. Moreover, there is a similar case for the entire group of α-synucleinopathies, which are all characterized by the pathological accumulation of aggregated α-synuclein (α-Syn) in the brain and other tissues. In different biological materials (blood, cerebrospinal fluid, saliva, or skin), α-Syn exists in various conformations and various aggregated states depending on the surrounding environment. Lewy bodies have been considered a pathognomonic feature of Parkinson's disease for over 100 years, and α-Syn has been known to be a key component of Lewy bodies for over 25 years, making it possible to confirm the diagnosis by

Indexed as

alpha-synucleinbiomarkersParkinson’s diseaseRT-QuICseed amplification assays

Identifiers

PMID40496124
PMCPMC12149741

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.