Evidence map›Paper›PMID 40496081›Full record

ArticleRadiology case reports2025

Unraveling septal perfusion abnormalities in Ebstein's anomaly: A case report contrasting PET MPI with myocardial reality.

Haluk Alibazoglu, Adam M Khalil, Deniz Alibazoglu, Ahmed Sherif, Ahmed Bafadel, Amany Hillis, Hidayath A Ansari, Hani Sabbour, Buket Alibazoglu, Rawan A Hussein and 1 more

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Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Haluk AlibazogluImaging Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Adam M KhalilMedical School, Weill Cornell Medicine, Doha, Qatar.
Deniz AlibazogluMedical School, American University of the Caribbean School of Medicine, St. Marteen.
Ahmed SherifImaging Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Ahmed BafadelHeart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Amany HillisDept. of Cardiology, SEHA, Abu Dhabi, UAE.
Hidayath A AnsariImaging Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Hani SabbourDept. of Cardiology, Mediclinic Abu Dhabi, Abu Dhabi, UAE.
Buket AlibazogluDept. of Cardiology, CardioCheck, Ankara, Turkey.
Rawan A HusseinDept. of Imaging, Tawam Molecular Imaging Center, AlAin, UAE.
Mohammed E KhalilHeart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Ebstein's anomaly, septal perfusion abnormality poses a challenge in traditional interpretations of myocardial blood flow. We report a single case of a 43-year-old female with known Ebstein's anomaly who was referred for preoperative cardiac evaluation prior to bariatric surgery. Due to her multiple cardiovascular risk factors and vague chest discomfort, positron emission tomography (PET) myocardial perfusion imaging (MPI) and cardiac magnetic resonance imaging (MRI) were performed. PET MPI demonstrated a partially reversible septal perfusion defect involving 30% of the left ventricular myocardium with fixed (12%) and ischemic (18%) components, while gated images revealed preserved wall motion. Cardiac MRI confirmed normal septal wall thickness and no myocardial fibrosis. These findings suggest that dyssynchronous atrial contraction and a shortened diastolic perfusion window associated with atrialization of the right ventricle are responsible for the observed perfusion abnormality rather than coronary artery disease or myocardial scar.

Indexed as

Dyssynchronous atrial systoleEbstein's anomalyMyocardial perfusion imagingPET MPI

Identifiers

PMID40496081
PMCPMC12150035

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