ArticleFrontiers in medicine2025
Global burden of pancreatitis among individuals aged 15-39 years: a systematic analysis from the 2021 GBD study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global landscape and knowledge structure of research on pancreatitis and gut microbiota: a bibliometric analysis based on WoSCC and Scopus (2006 - 2025).Frontiers in cellular and infection microbiology · 2026Pooled it
- Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection.Journal of hepato-biliary-pancreatic sciences · 2026Article
- C - reactive protein to albumin ratio as predictor of severity and outcome in acute pancreatitis.Bioinformation · 2026Article
- Global, Regional, and National Burden of Pancreatitis in Adults Aged 20-54 Years, 1990-2021: Insight from the Global Burden of Disease Study 2021.Digestive diseases and sciences · 2025Article
- Global burden of acute pancreatitis attributable to high alcohol intake from 1990 to 2021: findings and prevention potential based on GBD 2021.BMC gastroenterology · 2025Article
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Authors and funding
3 authors.
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Abstract
Background: Pancreatitis represents a significant global public health challenge, yet there is a lack of comprehensive analyses focusing on the burden of pancreatitis and its long-term trends among young individuals aged 15-39 years. Methods: This study utilized data from the Global Burden of Disease (GBD 2021) database to analyze the prevalence, incidence, and disability-adjusted life years (DALYs) associated with pancreatitis in the 15-39 age group from 1990 to 2021. Temporal trends in disease burden were assessed by calculating the estimated annual percentage change (EAPC), with point estimates and their 95% uncertainty intervals (UIs) reported. Results: Between 1990 and 2021, the global number of cases related to pancreatitis-including prevalence, incidence, DALYs, and deaths-substantially increased in the 15-39 age group. However, age-standardized rates for prevalence, incidence, DALYs, and mortality showed a declining trend. Gender-specific analysis revealed that females had lower prevalence and incidence rates compared to males. Socio-demographic Index (SDI)-based subgroup analysis indicated that low-SDI regions experienced the largest increases in DALYs and deaths, while high-SDI regions showed the most significant declines in age-standardized DALYs and mortality rates. Geographically, East Asia demonstrated the largest decrease in the burden of pancreatitis, whereas Western Sub-Saharan Africa exhibited the highest increases in case numbers and deaths. Age-stratified analysis showed that individuals aged 35-39 years had the greatest increases in case numbers and disease burden, despite experiencing the most notable decline in incidence rates. Conversely, the 15-19 age group exhibited reductions in disease burden and mortality rates. Conclusion: This study highlights that, while the global number of pancreatitis cases among young individuals aged 15-39 has risen from 1990 to 2021, the overall disease burden has declined, particularly in high-income regions. In contrast, the disease burden in low-income regions continues to rise.
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