ArticleWorld journal of gastroenterology2025
Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis.
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Austrian Society of Gastroenterology and Hepatology (ÖGGH) consensus on primary biliary cholangitis.Wiener klinische Wochenschrift · 2026Article
- The Role of Laboratory Markers in Primary Biliary Cholangitis: A Clinical Review and a Case Report.Biomedicines · 2026Review
- Autoantibodies in Primary Biliary Cholangitis: From Classical Markers to Emerging Targets.Journal of clinical medicine · 2025Review
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Authors and funding
9 authors.
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Abstract
backgroundThe diagnosis of primary biliary cholangitis (PBC) remains challenging, particularly in cases where anti-mitochondrial antibody (AMA), anti-mitochondrial E2 subunit antibody (AMA-M2), anti-glycoprotein 210 (anti-gp210), and anti-speckled protein 100 (anti-Sp100) are all negative. In such instances, the condition is often confirmed through a liver needle biopsy.
aimTo identify additional plasma biomarkers for non-invasive diagnostic methods of PBC.
methodsWe utilized the Sengenics KREX™ immunome protein array to identify potential biomarkers for the diagnosis of PBC. Subsequently, we validated the predictive capability of the RPL30 antibody through an ELISA and retrospectively analyzed its association with the clinical features of 17 autoantibody-negative PBC cases and 45 autoantibody-positive PBC cases.
resultsIn our study we observed that RPL30 demonstrated the highest fold-change difference in PBC, with a penetrance frequency of 40% and a penetrance fold change of 38.30147. The analysis of anti-RPL30 optical density values between patients with AMA/AMA-M2/anti-gp210/anti-Sp100-negative PBC (autoantibody-negative PBC) and healthy controls using a receiver operating characteristic curve yielded an area under the curve of 0.853. This analysis established an optimal cutoff value of 0.0708, achieving 100% specificity and 75% sensitivity. The combination of anti-RPL30 and other autoantibodies elevated the diagnosis rate of PBC from 61.29% to 79.00% (
conclusionOur study highlighted the potential of anti-RPL30 as a promising biomarker for diagnosing PBC, particularly in autoantibody-negative cases.
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