ArticleGlobal medical genetics2025
Gene frequency and distribution of human platelet antigen-1 to -6, -10, -15, and -21 of platelets donors in Wuhan, China.
Article in Global medical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: In this study, the frequency of human platelet antigen (HPA) alleles and genotypes of platelet donors in Wuhan was evaluated and differences in HPA distribution between Wuhan and other regions in China were compared. Study Design and Methods: HPA genotyping was performed using RT-qPCR in 1516 platelet donors in Wuhan. The allele frequencies of HPA-1 to -6, -10, -15, and -21 were calculated and evaluated according to the Hardy-Weinberg principle. Mismatch probability was calculated for each HPA system. The distribution and features of HPA systems in Wuhan were compared to those of other regions in China. Results: The observed allele frequencies and expected frequencies of HPA-1 to -6, -10, -15, and -21 showed no significant differences according to the Hardy-Weinberg principle (all Conclusion: Distinct gene frequencies and genotypes were observed for HPA-1 to -6, -10, -15, and -21 among 1516 platelet donors from Wuhan compared with those of other regions. These results highlight the fact that HPA genotyping is of great significance for the establishment of HPA genotype registry and precise platelet transfusion in Wuhan.
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