Evidence map›Paper›PMID 40495885›Full record

ArticleFrontiers in pharmacology2025

Anticancer effects of zinc ion-mediated DNA demethylation in oesophageal squamous cell carcinoma.

Bin Zhou, Changchun Wang, Yueyu Huang, Xuping Yang, Ting Ye, Lize Shen, Qiaoli Lv, Weimin Mao, An Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bin Zhou *Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Changchun Wang *Department of Thoracic Surgery, Zhejiang Cancer Hospital, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China.
Yueyu Huang *Zhejiang Cancer Institute, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Xuping Yang *Postgraduate training base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.
Ting YeDepartment of Clinical Laboratory, Taixing People's Hospital, Yangzhou University, Taizhou, China.
Lize ShenLC-Bio Technologies, Hangzhou, Zhejiang, China.
Qiaoli LvJiangxi Key Laboratory of Tumour Metastasis of Jiangxi Health Commission, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China.
Weimin MaoPostgraduate training base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.
An ZhaoZhejiang Cancer Institute, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Abnormalities in trace elements and the incidence of oesophageal squamous cell carcinoma (ESCC) have been reported in China. Zinc ions (Zn Methods: Biological behaviour changes in ESCC cells treated with or without Zn Results: Zn Conclusion: Zn

Indexed as

biomarkerscombination drug therapyDNA methylationgene expressionmetallothioneinsoesophageal squamous cell carcinomazinc ions

Identifiers

PMID40495885
PMCPMC12149215

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.