ArticleWorld journal of psychiatry2025
Alterations of serum metabolic profile in major depressive disorder: A case-control study in the Chinese population.
Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Amino Acid-Fatty Acid Profile as a Novel Predictive Method in the Assessment of Diagnosis and Treatment Efficacy of Anxiety-Related Disorders and Mood Disorders.International journal of molecular sciences · 2026Review
- Modulation of the microbiota-lipid-brain axis by modified Chaihu-Longgu-Muli Decoction ameliorates chronic stress-induced depression.Frontiers in molecular neuroscience · 2026Article
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Authors and funding
7 authors.
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Abstract
backgroundMajor depressive disorder (MDD) is characterized by persistent depressed mood and cognitive symptoms. This study aimed to discover biomarkers for MDD, explore its pathological mechanisms, and examine the associations of the identified biomarkers with clinical and psychological variables.
aimTo discover candidate biomarkers for MDD identification and provide insight into the pathological mechanism of MDD.
methodsThe current study adopted a single-center cross-sectional case-control design. Serum samples were obtained from 100 individuals diagnosed with MDD and 97 healthy controls (HCs) aged between 18 to 60 years. Metabolomics was performed on an Ultimate 3000 UHPLC system coupled with Q-Exactive MS (Thermo Scientific). The online software Metaboanalyst 6.0 was used to process and analyze the acquired raw data of peak intensities from the instrument.
resultsThe study included 100 MDD patients and 97 HCs. Metabolomic profiling identified 35 significantly different metabolites (
conclusionOur study reported metabolites (some lipids, steroids, amino acids, carnitines, and alkaloids) responsible for discriminating MDD patients and HCs. This metabolite profile may enable the development of a laboratory-based diagnostic test for MDD. The mechanisms underlying the association between psychological or clinical variables and differential metabolites deserve further exploration.
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