Evidence map›Paper›PMID 40495831›Full record

ArticleWorld journal of psychiatry2025

Structural network communication differences in drug-naive depressed adolescents with non-suicidal self-injury and suicide attempts.

Shuai Wang, Jiao-Long Qin, Lian-Lian Yang, Ying-Ying Ji, Hai-Xia Huang, Xiao-Shan Gao, Zi-Mo Zhou, Zhen-Ru Guo, Ye Wu, Lin Tian and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neural Circuit Taxonomy and Precision Psychiatry in Major Depression.Advances in experimental medicine and biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shuai WangSchool of Wuxi Medicine, Nanjing Medical University, Wuxi 214000, Jiangsu Province, China.
Jiao-Long QinKey Lab of Intelligent Perception and Systems for High-Dimensional Information of Ministry of Education, School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210000, Jiangsu Province, China.
Lian-Lian YangSchool of Medicine, Jiangnan University, Wuxi 214000, Jiangsu Province, China.
Ying-Ying JiDepartment of Rehabilitation Medicine, The Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi 214000, Jiangsu Province, China.
Hai-Xia HuangDepartment of Medical Imaging, Huadong Sanatorium, Wuxi 214000, Jiangsu Province, China.
Xiao-Shan GaoSchool of Wuxi Medicine, Nanjing Medical University, Wuxi 214000, Jiangsu Province, China.
Zi-Mo ZhouSchool of Medicine, Jiangnan University, Wuxi 214000, Jiangsu Province, China.
Zhen-Ru GuoSchool of Medicine, Jiangnan University, Wuxi 214000, Jiangsu Province, China.
Ye WuSchool of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210000, Jiangsu Province, China.
Lin TianDepartment of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi 214000, Jiangsu Province, China.
Huang-Jing NiSchool of Computer Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210000, Jiangsu Province, China.
Zhen-He ZhouSchool of Wuxi Medicine, Nanjing Medical University, Wuxi 214000, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression, non-suicidal self-injury (NSSI), and suicide attempts (SA) often co-occur during adolescence and are associated with long-term adverse health outcomes. Unfortunately, neural mechanisms underlying self-injury and SA are poorly understood in depressed adolescents but likely relate to the structural abnormalities in brain regions.

aimTo investigate structural network communication within large-scale brain networks in adolescents with depression.

methodsWe constructed five distinct network communication models to evaluate structural network efficiency at the whole-brain level in adolescents with depression. Diffusion magnetic resonance imaging data were acquired from 32 healthy controls and 85 depressed adolescents, including 17 depressed adolescents without SA or NSSI (major depressive disorder group), 27 depressed adolescents with NSSI but no SA (NSSI group), and 41 depressed adolescents with SA and NSSI (NSSI + SA group).

resultsSignificant differences in structural network communication were observed across the four groups, involving spatially widespread brain regions, particularly encompassing cortico-cortical connections (

conclusionThis study provides evidence of structural network communication differences in depressed adolescents with NSSI and SA, highlighting impaired neuroanatomical communication efficiency as a potential contributor to their symptoms. These findings offer new insights into the pathophysiological mechanisms underlying the comorbidity of NSSI and SA in adolescent depression.

Indexed as

AdolescentsCommunication modelsDepressionNon-suicidal self-injuryStructural network efficiencySuicide attempts

Identifiers

PMID40495831
PMCPMC12147009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.