ArticleWorld journal of psychiatry2025
Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment.
Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Digital maze test reveals cognitive performance patterns associated with amyloid-β and tau.Neuropsychology · 2026Article
- Reframing Dementia Prevention Strategies Aligned with the WHO Global Action Plan: A Structured Narrative Review Focusing on Mild Behavioral Impairment.Neurology international · 2026Review
- Peripheral blood biomarkers and mild behavioral impairment in mild cognitive impairment: Clinical correlations and mechanistic insights.World journal of psychiatry · 2025Article
- Alteration of glucose neurometabolism and brain morphology in mild behavioral impairment: a neuroimaging study on cognitively healthy individuals.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
10 authors.
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Abstract
backgroundMild behavioral impairment (MBI) refers to the neurobehavioral symptoms observed in older adults that may be potential risk factors for neurodegenerative diseases. While a significant number studies have explored the association between cerebrospinal fluid and MBI, only a few have examined the connection between plasma biomarkers and MBI.
aimTo examine the prevalence of MBI in healthy older adults (HOAs) and individuals with mild cognitive impairment (MCI), as well as the association between MBI and plasma biomarkers of Alzheimer's disease (AD).
methodsWe enrolled a total of 241 subjects, which included 136 HOAs and 105 MCIs, from the Yuhua District of Shijiazhuang City, Hebei Province, China. The MBI symptom checklist (MBI-C) was utilized for the assessment and diagnosis of MBI, and a score of MBI-C ≥ 6.5 was considered indicative of the condition. Fasting venous blood samples were collected from 70 patients, 32 HOAs and 38 MCIs, and levels of amyloid β-protein (Aβ) 40, Aβ42, and hyperphosphorylated tau (p-Tau217) in these samples were measured using an enzyme-linked immunosorbent assay.
resultsThe prevalence of MBI in the HOAs and MCI groups was 4.4% and 15.3%, respectively (
conclusionBoth MCI and HOAs have exhibited a higher prevalence of MBI, with changes in impulse control behavior being the most common. MBI not only presents as an independent risk factor for cognitive decline but is also linked with AD-related peripheral biomarkers.
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