Evidence map›Paper›PMID 40495692›Full record

ReviewCancer science2025

Gastric Signet Ring Cell Carcinoma in a Helicobacter pylori-Positive 10-Year-Old Boy: A Case Report and Literature Review.

Xiaoxuan Li, Xinchi Luan, Wenjuan Yu, Shibo Wang, Xiangxue Li, Lihua Zhang, Siyi Zhang, Jialin Song, Jing Guo, Shasha Wang and 2 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Potassium-competitive acid blockers forFrontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoxuan LiDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.ORCID https://orcid.org/0009-0006-7419-433X
Xinchi LuanDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wenjuan YuDepartment of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Shibo WangDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xiangxue LiDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Lihua ZhangDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Siyi ZhangDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jialin SongDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jing GuoDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Shasha WangDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wensheng QiuDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.ORCID https://orcid.org/0000-0002-9817-1857
Jing LvDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.ORCID https://orcid.org/0000-0001-8482-1196

Funding

Qingdao Municipal Science and Technology Bureau 2023-2-018-YY
6 · The paper itself

Abstract

Gastric cancer is rare in pediatric populations, with gastric signet ring cell carcinoma (GSRCC) being an exceptionally infrequent subtype. We report a case of GSRCC in a 10-year-old Chinese boy with no family history of cancer. The diagnosis was established via gastroscopy, endoscopic ultrasound, and imaging examinations. Early detection allowed a successful distal gastrectomy with D2 lymph node dissection. Postoperative whole-exome sequencing (WES) revealed no clinically significant mutations but identified some somatic alterations. Notably, gastric biopsy pathology demonstrated strong positivity for Helicobacter pylori (H. pylori) infection. Additionally, we comprehensively reviewed the existing pediatric GSRCC cases, suggesting the potential role of H. pylori infection in the pathogenesis of pediatric gastric cancer.

Indexed as

Carcinoma, Signet Ring CellHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsChildExome SequencingGastrectomyGastroscopyHumansMaleHelicobacter pylori infectionpediatric gastric cancersignet ring cell carcinomawhole‐exome sequencing

Identifiers

PMID40495692
PMCPMC12317403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.