ArticleUltrasonography (Seoul, Korea)2025
Plaque biomarkers from high-frame rate vector flow imaging and shear wave elastography in mild carotid stenosis.
Article in Ultrasonography (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Vector Flow Imaging for Carotid Artery Stenosis Assessment: A Scoping Review.Diagnostics (Basel, Switzerland) · 2026Review
- Diagnostic performance of vector flow imaging-derived wall shear stress and radiofrequency echo-tracking-derived arterial stiffness indices in severe carotid stenosis.Ultrasonography (Seoul, Korea) · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
purposeThis study aimed to investigate the association of carotid plaque biomechanical parameters and elasticity-measured using high-frame rate vector flow imaging (VFI) and shear wave elastography (SWE)-with the occurrence of ipsilateral ischemic stroke in patients with mild stenosis.
methodsThe study included 122 patients with mild carotid stenosis involving a single plaque between September 2023 and April 2024 who underwent B-mode ultrasound, high-frame rate VFI, and SWE examinations. Based on head computed tomography or magnetic resonance imaging findings, participants were classified as symptomatic (with ipsilateral ischemic lesions) or asymptomatic. Wall shear stress, oscillatory shear index, and turbulence (Tur) index were quantified on both downstream and upstream plaque surfaces, and the Young modulus (YM) was measured for distinct plaque regions. Multivariate logistic regression models were employed to evaluate correlations between these imaging-derived parameters and ipsilateral ischemic stroke.
resultsA higher Tur index on the plaque's downstream surface and a lower mean YM within the plaque were significantly associated with ipsilateral ischemic stroke in patients with mild carotid stenosis. Moreover, the combined use of high-frame rate VFI and SWE demonstrated superior predictive performance for stroke risk compared with either modality alone.
conclusionHigh-frame rate VFI and SWE enable detection of biomechanical features and stiffness in high-risk plaques among patients with mild carotid stenosis. Their combined application may yield valuable non-invasive biomarkers for stratifying stroke risk in this population.
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