Evidence map›Paper›PMID 40495577›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Associations between Aβ deposition and neurometabolic alterations in Alzheimer's disease: Insights from hybrid 3D MRSI-PET imaging.

Miao Zhang, Jialin Hu, Yaoyu Zhang, Ziyu Meng, Yibo Zhao, Yudu Li, Wen Jin, Xiao-Hang Qian, Lijun Wang, Guanyu Ye and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Miao ZhangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jialin HuDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yaoyu ZhangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Ziyu MengDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yibo ZhaoBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Yudu LiBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Wen JinBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Xiao-Hang QianDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lijun WangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Guanyu YeDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu-Feng JiangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Ya-Dong LiDepartment of Gastroenterology, Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jian YeDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Huidong TangDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jun LiuDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Parashkev NachevHigh-Dimensional Neurology Group, Institute of Neurology, University College London, London, UK.
Zhi-Pei LiangBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Biao LiDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yao LiDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-5009-7443

Funding

Guangci Clinical Technology and Innovation Program(GCTIP)of Ruijin Hospital GCQH2023061Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2022QN035Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2023QNA46Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2023ZD22Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2025QNA45Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2025ZD31National Science Foundation of China 82151314National Science Foundation of China 82372073Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher LearningShanghai Municipal Health Commission 202240031Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University 21TQ1400203Shanghai Science and Technology Committee 21ZR1481500STI2030-Major Projects 2022ZD0212800Wellcome
6 · The paper itself

Abstract

introductionUnderstanding the neurometabolic changes associated with amyloid-β (Aβ) deposition is important for early Alzheimer's disease (AD) diagnosis, but their spatial relationships remained unexplored due to technical limitations.

methodsWe investigated the relationship between Aβ deposition and neuronal and glial metabolites using high-resolution 3D magnetic resonance spectroscopic imaging (MRSI) (8-min scan, 2 × 3 × 3 mm

resultsN-Acetylaspartate levels were negatively correlated with Aβ, while myo-inositol levels were positively correlated globally. Regional associations with Aβ include N-acetylaspartate reductions in frontal cortex, anterior cingulate cortex, and precuneus, and myo-inositol increases in precuneus, lateral temporal, and lateral parietal cortices. Combined MRSI and PET biomarkers achieved the highest diagnostic accuracy for MCI and AD . DISCUSSION: Hybrid high-resolution 3D MRSI and Aβ-PET imaging provides valuable insights into Aβ's impact on neurometabolic changes, improving early AD diagnosis. HIGHLIGHTS: Hybrid 3D magnetic resonance spectroscopic imaging-positron emission tomography (MRSI-PET) imaging reveals Aβ deposition impact on neurometabolism in Alzheimer's disease (AD). N-acetylaspartate (NAA) as a neuronal metabolic marker is negatively associated with Aβ globally and locally. Myo-inositol (mI) as a glial metabolic marker is positively associated with Aβ globally and locally. Combining 3D magnetic resonance spectroscopic imaging (MRSI) and PET biomarkers improves diagnostic accuracy for mild cognitive impairment (MCI) and AD.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainCognitive DysfunctionPositron-Emission TomographyAgedAged, 80 and overAspartic AcidCreatineFemaleHumansImaging, Three-DimensionalInositolMagnetic Resonance SpectroscopyMaleMiddle AgedAmyloid beta-PeptidesAspartic AcidCreatineInositolN-acetylaspartatealzheimer's diseaseamyloid‐βmagnetic resonance spectroscopic imagingmyo‐inositoln‐acetylaspartate

Identifiers

PMID40495577
PMCPMC12152366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.