ArticleJournal of medical imaging and radiation oncology2025
Exploration of Diffusion Tensor Imaging for Delineating Target Volume Boundary in Glioblastoma Radiotherapy.
Article in Journal of medical imaging and radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spatial patterns of progression in reported glioblastoma cohorts after upfront chemoradiation and salvage therapy: a systematic review and meta-analysis.Journal of neuro-oncology · 2026Pooled it
- White matter pathlength maps from diffusion-weighted MRI tractography for radiotherapy target planning in glioblastoma.Journal of neuro-oncology · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
purposeThe objective of this study is to investigate the variations in diffusion tensor imaging (DTI) parameters at different distances surrounding the operative cavity, with a specific focus on exploring the potential utility of DTI in accurately delineating radiotherapy clinical target volume for glioblastoma patients.
methodsA retrospective study was conducted on 41 patients with glioblastoma, in which apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured at various distances beyond the surgical cavity. Recurrent patients were prospectively followed up according to the RANO criteria, aiming to investigate discrepancies between ADC and FA values in recurrent regions compared to normal control tissues prior to recurrence.
resultsThe rADC and rFA ratio approach 1 at a distance of 3 cm beyond the cavity. At the edge of the operative cavity and 2 cm beyond, the subtotal resection (STR) group exhibited higher ADC and rADC values compared to the gross total resection (GTR) group (p < 0.05). Similarly, FA and rFA values in the STR group were lower than those in the total resection group both at 1 cm beyond and 2 cm beyond (p < 0.05). Conventional MRI did not reveal any abnormalities prior to marginal or distant recurrence; however, the ADC value within this region was higher than that of control normal tissues (p = 0.023).
conclusionsThe margins of GBM tumour invasion are typically not isotropic and could be > 2 cm and sometimes up to 3 cm. We recommend appropriately larger expansion of the target volume for patients with subtotal tumour resection. The utilisation of DTI in delineating the boundary of GBM's radiotherapy clinical target volume represents a promising avenue that holds potential to enhance precision and accuracy.
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