Evidence map›Paper›PMID 40495465›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Multifunctional Organelle-Targeting Probes for Intracellular Imaging and Enhanced Cancer Phototherapy.

Weijun Ma, Chen Xie, Xiaomin Li, Leo K B Tam, Yue Wu, Rui Wang, Pak-Lun Lam, Ho-Fai Chau, Ka-Leung Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weijun MaDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.
Chen XieDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.ORCID https://orcid.org/0000-0003-0998-3245
Xiaomin LiDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.
Leo K B TamDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.
Yue WuDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.ORCID https://orcid.org/0000-0001-7296-8182
Rui WangDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.
Pak-Lun LamDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.
Ho-Fai ChauDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.ORCID https://orcid.org/0000-0001-6964-1840
Ka-Leung WongDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region of China.ORCID https://orcid.org/0000-0002-3750-5980

Funding

Hong Kong Research Grants Council 12300021NSFC/RGC Joint Research Scheme N_PolyU209/21
6 · The paper itself

Abstract

Photodynamic therapy (PDT) represents a promising modality for cancer treatment; however, its clinical application is hindered by challenges such as glutathione (GSH)-mediated quenching of reactive oxygen species (ROS) and autofluorescence interference during visible light imaging. This study introduces Cy-NBD-5F, a photosensitizer engineered to address these limitations. Upon activation by GSH, Cy-NBD-5F exhibits 5.5-fold fluorescence enhancement at 701 nm, producing its reduced form, Cy-OH-5F, which demonstrates enhanced ROS generation, including a 1.4-fold increase in singlet oxygen and 1.2-fold increase in superoxide anion radicals. Under light irradiation, Cy-OH-5F induces significant cytotoxicity (IC

Indexed as

Fluorescent DyesNeoplasmsOrganellesPhotosensitizing AgentsCell Line, TumorEndoplasmic ReticulumGlutathioneHeLa CellsHumansLysosomesOptical ImagingPhotochemotherapyReactive Oxygen SpeciesSinglet OxygenFluorescent DyesGlutathionePhotosensitizing AgentsReactive Oxygen SpeciesSinglet Oxygenactivatable fluorescencedual‐targetinghemicyanine dyenir emissionphotodynamic therapy

Identifiers

PMID40495465
PMCPMC12238914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.