ArticleAnnals of Indian Academy of Neurology2025
Cardiac Magnetic Resonance Imaging Markers in Idiopathic Inflammatory Myopathy - A Prospective Observational Study.
Article in Annals of Indian Academy of Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A Prospective Study on Autonomic Functions in Idiopathic Inflammatory Myopathies: The AFIIM Study.Annals of Indian Academy of Neurology · 2026Article
- Molecular Bases of Myopathies and Their Impact on Clinical Practice: Advances and Future Perspectives.International journal of molecular sciences · 2026Review
- Cardiac Magnetic Resonance Imaging Markers in Idiopathic Inflammatory Myopathy: Correspondence.Annals of Indian Academy of Neurology · 2025Article
- Optimizing Cardiac Assessment in Idiopathic Inflammatory Myopathies.Annals of Indian Academy of Neurology · 2025Article
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Authors and funding
15 authors.
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Abstract
BACKGROUND AND
objectivesIdiopathic inflammatory myopathies (IIMs) encompass a spectrum of conditions with diverse muscular and extra-muscular symptoms, including cardiac manifestations, which significantly impact morbidity and mortality. Our study aims to assess cardiac involvement markers in IIM using cardiac magnetic resonance imaging (CMR) and evaluate their association with disease severity.
methodsWe recruited 62 participants prospectively, including 31 clinically suspected IIM patients and 31 healthy controls who were matched by age and sex. CMR with multiparametric mapping (1.5 T magnetic resonance imaging) and the Myositis Disease Activity Assessment Tool (MDAAT) were used in the evaluation.
resultsWith a mean age of 35.3 ± 12.2 years and a female preponderance (F:M = 2.4:1), the majority of the study population (77.4%) exhibited positive myositis-specific antibodies, whereas 45.2% had myositis-associated antibodies. Cardiac symptoms were reported by 45.2% of the cases, while 48.3% had an MDAAT cardiac Visual Analog Scale (VAS) score of ≥1, indicating potential cardiac involvement. Cases had significantly higher native T1 and T2 mapping values (1085.7 ± 57.7 vs. 1043.3 ± 36.1 ms, P = 0.002 and 52.9 ± 4.3 vs. 50.4 ± 2.6 ms, P = 0.011, respectively). Late gadolinium enhancement was seen in 6.4%. The native T1 value positively correlated with the MDAAT total score (ρ = 0.376, P < 0.014) and cardiac VAS score (ρ = 0.259, P = 0.038). A native T1 value ≥1048.25 ms has 72.7% sensitivity and 51.4% specificity (AUC = 0.711, P = 0.019) in detecting cardiac involvement.
conclusionsClinical parameters and CMR multiparametric mapping are shown to be correlated in this prospective investigation. It is the first study to look at the cardiac mapping parameters' sensitivity and specificity to MDAAT-based cardiac involvement. In the Indian population with IIM, it is the first assessment of cardiac involvement utilizing CMR. In IIM, this endeavor is expected to greatly improve early detection, prevention, and treatment of cardiac complications.
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