ArticlePhysiological reports2025
Sex and age differences in the association between heart rate variability and cardiac chronotropy: A replication-extension study.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Sex and age differences in the association between heart rate variability and cardiac chronotropy: A replication-extension study.Physiological reports · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Using heart rate variability (vmHRV) as a proxy of cardiac vagal modulation, previous studies have hinted at sex differences in the vagal control of cardiac chronotropy in young adults, but little is known in older individuals. The current study aimed at investigating for the first time the moderating role of both sex and age in the relationship between vmHRV and cardiac chronotropy in younger (n = 106, mean age: 19.9 (3.5) years) and older (n = 109, mean age: 72.8 (2.6) years) individuals. Further, we explored the effects of hormone replacement therapy on such association in a sub-sample of post-menopausal women (n = 17). Resting measures of the average inter-beat interval (IBI, as index of cardiac chronotropy) and vmHRV were collected. The results indicate (i) stronger associations between vmHRV and IBI in young adults and post-menopausal women compared to age-matched men, (ii) a weaker or no association in older women and men, respectively, and (iii) no effects of hormone replacement therapy in post-menopausal women. This study provides evidence of sex and age differences in the association between vmHRV and cardiac chronotropy, offering novel insight into vagal mechanisms of cardiac chronotropic control that may inform our understanding of sex- and age-related vulnerability to negative health outcomes.
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Registered trials
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