SynthesisRespirology (Carlton, Vic.)2025
Upper Airway Control Therapy (U-ACT): The Development of a Non-Pharmacological Intervention for Inducible Laryngeal Obstruction.
Synthesis in Respirology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Upper Airway Control Therapy (U-ACT): The Development of a Non-Pharmacological Intervention for Inducible Laryngeal Obstruction.Respirology (Carlton, Vic.) · 2025Pooled it
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
BACKGROUND AND
objectiveNon-pharmacological intervention is the recommended gold standard for inducible laryngeal obstruction (ILO) treatment. Despite this, there is no standardised approach and interventions are poorly described. The objective was to develop and describe a standardised non-pharmacological intervention for ILO, for future testing of effectiveness.
methodsMRC guidelines for complex intervention development were followed; the methodological approach was structured using the INDEX principles. The multi-phase research stages were: (1) evidence review; (2) qualitative data collection from speech and language therapists (n = 7) and patients (n = 22); (3) intervention design and theoretical underpinning; (4) prototype survey feedback from Stage 2 participants; and (5) final intervention description, using a validated reporting framework.
resultsSystematic review and synthesis of 14 studies (n = 527) identified key uncertainties and steered Stage 2 interviews. Framework analysis of qualitative data collected identified five overarching key themes for inclusion. The resulting 'Upper Airway Control Therapy' (U-ACT) intervention comprises two core components (education & empowerment; reliever breath control), four supporting components (bio-feedback training; prevention methods; supporting co-existing conditions; managing others' reactions to ILO) and a cross-cutting home practice component. U-ACT's mechanisms of action to bring about change includes 36 behaviour change techniques. Feedback on U-ACT protype was extremely positive; survey responders (n = 23; 87% response rate) strongly agreed to acceptability statements for all parameters surveyed [5-point Likert scale; median (range), 4.5, 3-5].
conclusionThe U-ACT intervention, developed with keystakeholders and underpinned with a programme theory, is fully manualised and ready for evaluation. If future testing proves clinical and cost effectiveness, it could be incorporated into existing ILO services.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.