ArticleMusculoskeletal care2025
Associations of Physical Activity, Sedentary Behaviour, Pain, Function and Quality of Life With Diabetes and Knee Osteoarthritis: Data From the Osteoarthritis Initiative.
Article in Musculoskeletal care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation.Journal of translational medicine · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relation of radiographic knee osteoarthritis (RKOA) and type 2 diabetes mellitus (T2DM) to physical activity, pain, physical function, and quality of life.
methodsData on physical activity (light and moderate-vigorous physical activity minutes/day, steps/day, sedentary time percent of wear time), pain, physical function (Western Ontario and McMaster Index, walking speed during 20-m walk) and quality of life (SF-12) from the Osteoarthritis Initiative at the 48-month visit were included. Participants (n = 1788) were categorised into no RKOA or T2DM, RKOA-alone, T2DM-alone, and RKOA and T2DM. Multivariable regression models, adjusted for age, sex, and BMI, assessed the relationship of disease status to outcomes.
resultsCompared to RKOA-alone, RKOA and T2DM were associated with lower moderate-vigorous physical activity (Coefficient: 4 min/day, 95% CI: [-7, -1]) and steps/day (-817 steps/day [-1291, -343]) and higher sedentary time percent (1.3%/day [-0.2, 2.8]). No significant differences were found in light physical activity (-11 min/day [-25, 2]). The RKOA and T2DM groups reported greater pain (1.0 [0.4, 1.6]) and functional limitations (3 [1, 5]), slower walking speed (-0.09 m/s [-0.12, -0.05]), and worse quality of life (-3.2 [-4.8, -1.6]). T2DM-alone was also associated with lower physical activity and worse quality of life than RKOA-alone.
conclusionsThe comorbidity of RKOA and T2DM and T2DM-alone were associated with lower physical activity and worse quality of life than RKOA-alone. Management should address both conditions concurrently rather than in isolation.
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