Evidence map›Paper›PMID 40495266›Full record

ArticleBritish journal of clinical pharmacology2026

Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers.

Alexandre O Gérard, Diane Merino, Marc Labriffe, Fanny Rocher, Delphine Viard, Laurence Zemori, Thibaud Lavrut, Erik M Donker, Joost D Piët, Jean-Paul Fournier and 2 more

Abstract read
In one paragraph

Article in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Reimagining pharmacology education.Pharmacological reviews · 2026
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandre O GérardUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.ORCID https://orcid.org/0000-0001-6591-6966
Diane MerinoUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.ORCID https://orcid.org/0000-0001-7669-2339
Marc LabriffePharmacology and Transplantation, INSERM U1248, Université de Limoges, Limoges, France.ORCID https://orcid.org/0000-0001-5840-8904
Fanny RocherUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.
Delphine ViardUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.ORCID https://orcid.org/0000-0001-6140-4664
Laurence ZemoriUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.
Thibaud LavrutUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.
Erik M DonkerResearch and Expertise Centre in Pharmacotherapy Education (RECIPE), Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-8169-0714
Joost D PiëtResearch and Expertise Centre in Pharmacotherapy Education (RECIPE), Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0000-7380-4876
Jean-Paul FournierUniversité Côte d'Azur, Faculty of Medicine of Nice, Medical Simulation Center, Nice, France.ORCID https://orcid.org/0000-0002-1363-5107
Milou-Daniel DriciUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.ORCID https://orcid.org/0000-0003-4121-530X
Alexandre DestereUniversité Côte d'Azur Medical Centre, Department of Clinical Pharmacology and Pharmacovigilance Center, Nice, France.ORCID https://orcid.org/0000-0001-6147-9201

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsIn medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics (CPT) exams, comparing their results to medical students and exploring their ability to identify poorly formulated multiple-choice questions (MCQs).

methodsChatGPT-4 Omni, Gemini Advanced, Le Chat and DeepSeek R1 were tested on local CPT exams (third year of bachelor's degree, first/second year of master's degree) and the European Prescribing Exam (EuroPE

resultsLLMs achieved comparable or superior results to medical students across all levels. For local exams, LLMs outperformed M1 students and matched L3 and M2 students. In EuroPE

conclusionLLMs demonstrate capabilities comparable to or exceeding medical students in CPT exams. Their ability to flag potentially flawed MCQs highlights their value not only as educational tools but also as quality control instruments in exam preparation.

Indexed as

Educational MeasurementEducation, Medical, UndergraduateLarge Language ModelsPharmacology, ClinicalClinical CompetenceHumansStudents, Medicallarge language modelmedical studypedagogypharmacology, therapeutics

Identifiers

PMID40495266
PMCPMC13420888

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.