ArticleDiabetology & metabolic syndrome2025
Polycystic ovary syndrome and risk of pregnancy-induced hypertension, gestational diabetes mellitus, and preeclampsia: a Bayesian Mendelian randomization study.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Lipidomic signatures in gestational diabetes mellitus and postpartum type 2 diabetes mellitus: a narrative review of etiologic and predictive implications.EBioMedicine · 2026Review
- East Asian Mendelian-Randomization Evidence Linking PCOS to Gestational Diabetes Mellitus.International journal of women's health · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundObservational studies have shown an increased incidence of pregnancy complications in women with polycystic ovary syndrome (PCOS), but some controversy remains.
objectiveTo investigate the causal association of polycystic ovary syndrome with pregnancy-induced hypertension (PIH), gestational diabetes mellitus (GDM), and preeclampsia (PEC) using two-sample Mendelian randomization (MR).
methodsGWSA data from European populations were collected and causal analyses of PCOS (N = 113238) with PIH (N = 123579/118990), GDM (N = 123579/116363), and PEC (N = 123579/118291) were performed using mainly inverse variance weighted (IVW) method, along with Bayesian analysis to improve the accuracy of the results. Subsequently, heterogeneity, horizontal pleiotropy test and MR Steiger test were performed to assess the robustness of the results and the strength of causality. Finally, a brief bioinformatics analysis was performed.
resultsThere was a positive causal association between PCOS and PIH, whereas there was no causal association with PEC and GDM, and no heterogeneity or pleiotropy was detected.
conclusionsOur study demonstrates for the first time a causal association between PCOS and PIH and provides relevant mutation loci for subsequent studies from a genetic perspective.
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