ArticleLipids in health and disease2025
Association of sex hormone-binding globulin and dyslipidemia with Japanese postmenopausal women: a cross-sectional study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Insulin Levels Early in Perimenopause Inform Vasomotor Symptom Incidence Across the Menopausal Transition.The Journal of clinical endocrinology and metabolism · 2026Article
- Beyond Estrogen: Distribution and Hormonal Correlates of Serum Testosterone Among Postmenopausal U.S. Women, NHANES 2011-2016 and 2021-2023.Journal of clinical medicine · 2026Article
- Testosterone-related indices and adverse glucose-lipid metabolic status in men: a single-center retrospective study.Frontiers in endocrinology · 2026Article
- Insulin levels early in perimenopause inform vasomotor symptom incidence across the menopausal transition.medRxiv : the preprint server for health sciences · 2025Article
- Leukocyte-Based Inflammatory Profiles Across Dyslipidemia Phenotypes: Patterns of Eosinophil-Related Indices.Medicina (Kaunas, Lithuania) · 2025Article
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12 authors.
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Abstract
backgroundIn postmenopausal women, lower levels of sex hormone-binding globulin (SHBG) have been linked to various metabolic conditions. The association between SHBG levels and the presence of dyslipidemia was investigated in comparison with other sex hormones.
methodsData from 570 postmenopausal women were analyzed. To assess the relationship between circulating sex hormone concentrations and dyslipidemia, logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the relationships.
resultsParticipants had a median age of 51.0 years (49.0-53.0). The multivariate analysis revealed that SHBG levels were significantly associated with dyslipidemia. Specifically, low SHBG levels correlated with hypertriglyceridemia and low high-density lipoprotein levels. The area under the curve (AUC) and the optimal SHBG level cutoff value for identifying the presence of dyslipidemia were 0.626 and 69.0 nmol/L, respectively. The AUCs for SHBG levels were highest for estradiol (E2), total testosterone (TT) and dehydroepiandrosterone sulfate (DHEAS) levels.
conclusionsSHBG levels were significantly associated with dyslipidemia in postmenopausal women and outperformed E2, TT, and DHEAS levels. These findings highlight SHBG as a potential biomarker for dyslipidemia risk in postmenopausal women, warranting further research into its prognostic utility.
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