Trial reportAntimicrobial resistance and infection control2025
Continuous versus intermittent cuff pressure monitoring in preventing ventilator-associated pneumonia: a multicentre randomised controlled trial.
Trial report in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.Intensive care medicine · 2026Trial
- Nasotracheal Versus Orotracheal Intubation in Critically Ill COVID-19 Patients: A Retrospective Study.International journal of general medicine · 2026Article
- Bidirectional Relationship Between Systemic Immune-Inflammation Index and Postoperative Pneumonia in Elderly Patients Undergoing Colorectal Cancer Surgery: A Retrospective Cohort Study.Clinical interventions in aging · 2026Article
- Risk factors analysis and prediction model construction of LRTI in head and neck cancer patients with tracheostomy based on subglottic sputum aspiration volume.Frontiers in oral health · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundWhile continuous cuff pressure monitoring (CCPM) offers theoretical advantages in patients with ventilator-associated pneumonia (VAP), its clinical benefits remain controversial. This study aimed to investigate whether CCPM reduces VAP incidence compared with intermittent cuff pressure monitoring (ICPM) and its impact on nursing workload.
methodsWe conducted a multicentre, open-label randomised controlled trial across eight tertiary hospitals in China. Adult intensive care unit (ICU) patients requiring mechanical ventilation for ≥ 48 h were randomly assigned (1:1) to CCPM (n = 105) or ICPM (n = 108). Patients with tracheotomy, nasotracheal intubation or contraindications for semi-recumbent positioning were excluded. Randomisation was conducted using sealed opaque envelopes. The primary outcome was VAP incidence, diagnosed per Chinese Respiratory Society guidelines. Secondary outcomes included nursing workload, the percentage of time cuff pressure (Pcuff) was maintained at the target range (25–30 cm H2O), the duration of mechanical ventilation, ICU stay and ICU mortality.
resultsThe VAP incidence did not differ significantly between the CCPM and ICPM groups (16.2% vs. 17.6%; P = 0.79), but the CCPM group significantly reduced the cumulative time spent on Pcuff adjustments within 48 h (85 s vs. 660 s; P < 0.001). The percentage of Pcuff determinations within the target range was higher with CCPM (96.9% vs. 70.7%; P < 0.001). No significant differences were found in mechanical ventilation duration, ICU stay or ICU mortality (all P > 0.05).
conclusionContinuous cuff pressure monitoring did not reduce VAP incidence compared with ICPM but significantly decreased nursing workload and improved Pcuff control, suggesting that CCPM may serve as an efficient alternative for Pcuff management, thereby benefiting clinical workflow without compromising patient outcomes.
trial registrationChinese Clinical Trial Registry, ChiCTR2300077728. Registered 17 November 2023 – registered, https://www.chictr.org.cn/showproj.html?proj=190428 .
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