Trial reportJournal of translational medicine2025
Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial.
Trial report in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Effects of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Pulmonary Lobectomy: A Randomised, Single-Blind Controlled Clinical Trial.Actas espanolas de psiquiatria · 2025Trial
- Perioperative neurocognitive disorders in older patients: a narrative review of current knowledge in 2026.Perioperative medicine (London, England) · 2026Review
- Loganin alleviates sevoflurane-induced cognitive dysfunction and neuroinflammation in aged mice via modulation of SIRT1/NF-κB signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review).International journal of molecular medicine · 2026Review
- A cross-sectional analysis of research waste in randomized controlled trials on postoperative cognitive dysfunction.Scientific reports · 2026Article
- Probiotics and Phytoantioxidants as Emerging Neuroprotective Strategies: Bridging the Therapeutic Gap in Open Heart Surgery-Induced Brain Injury.Biomedicines · 2026Review
- Effects of spontaneous breathing anesthesia on postoperative cognitive dysfunction in elderly patients: a narrative review.Frontiers in surgery · 2026Review
- From Bench to Bedside: New Frontiers in Understanding and Treating Postoperative Delirium.Journal of clinical medicine · 2025Review
- Gut-Brain Axis and Perioperative Gut Microbiome in Postoperative Cognitive Dysfunction: Implications for Neurosurgical Patients.Medical sciences (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPostoperative cognitive dysfunction (POCD) may last for days, months or even years, leading to prolonged hospitalization and increased costs, increased mortality, and poor quality of life. Although POCD is an important clinical problem, its prevention, treatment strategies and effects are still limited. Therefore, this study aims to investigate the preventive effect of perioperative probiotic intervention on POCD in elderly patients, and further explore the mechanism of probiotics in improving postoperative cognitive function.
methodsAfter obtaining ethical approval and written informed consent, 190 patients aged 65 years or older scheduled for elective lower-extremity orthopedic surgery were enrolled in this randomized, single-center, double-blind trial. Enrolled patients were randomized to probiotic or control groups receiving either probiotics or placebo (210 mgx4/dose orally, 2 times/day) from 1 day before surgery to 5 days after surgery. The primary outcome was the cognitive function assessed by Mini-mental State Examination (MMSE) on admission, the first day, the third day and the seventh day after surgery. The secondary outcomes included perioperative changes in plasma IL-1β, IL-6 and BDNF, postoperative pain intensity, perioperative activities of daily living (ADL), faecal microbiota composition and changes of intestinal metabolites
resultsThe incidence of POCD in the probiotic group was significantly lower than in the control group (6 of 90 patients [6.7%] vs. 16 of 93 patients [17.2%], P = 0.028). In addition, the plasma levels of proinflammatory cytokines IL-1β and IL-6 were significantly lower and BDNF levels were significantly higher in the probiotic group than in the control group 1-2 days after surgery (U = 173.0, P < 0.01; U = 139.0, P < 0.01; U = 207.0, P < 0.01).
conclusionPerioperative probiotic intervention can reduce the incidence of POCD in elderly patients, which may improve cognitive function by inhibiting inflammatory response after anesthesia and surgery, and altering the composition of the postoperative gut microbiota and intestinal metabolites.
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