Evidence map›Paper›PMID 40495203›Full record

ArticleAddiction science & clinical practice2025

The peers expanding engagement in stimulant harm reduction with contingency management study: a protocol paper.

Alexis Cooke, Erin Stack, Linda Peng, Ryan Cook, Bryan Hartzler, Gillian Leichtling, Christi Hildebran, Judith M Leahy, Kelsey Smith Payne, Lynn E Kunkel and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction science & clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05700994 (Peer Engagement in Methamphetamine Harm-Reduction With Contingency Management), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05700994 naactive not recruitingnot on this map

Peer Engagement in Methamphetamine Harm-Reduction With Contingency Management (PEER-CM)

TypeinterventionalSponsorOregon Health and Science UniversityRan2023 to 2026Enrolled1,283ConditionsMethamphetamine AbuseArmsPeer Contingency Management, Standard of Care Contingency Management
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexis CookeComagine Health, 650 NE Holladay Street, Portland, OR, 97232, USA. acooke@comagine.org.
Erin StackComagine Health, 650 NE Holladay Street, Portland, OR, 97232, USA.
Linda PengDepartment of Medicine, Division of General Internal Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.
Ryan CookDepartment of Medicine, Division of General Internal Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.
Bryan HartzlerAddictions, Drug & Alcohol Institute, University of Washington, Seattle, USA.
Gillian LeichtlingComagine Health, 650 NE Holladay Street, Portland, OR, 97232, USA.
Christi HildebranComagine Health, 650 NE Holladay Street, Portland, OR, 97232, USA.
Judith M LeahyHealth Systems Division, Oregon Health Authority, Portland, OR, USA.
Kelsey Smith PayneHealth Systems Division, Oregon Health Authority, Portland, OR, USA.
Lynn E KunkelDepartment of Medicine, Division of General Internal Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.
Kim HoffmanDepartment of Medicine, Division of General Internal Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.
P Todd KorthuisDepartment of Medicine, Division of General Internal Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.

Funding

Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Peer Engagement in Methamphetamine Harm-Reduction with Contingency Management (PEER-CM)R01DA057670 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Philip Todd Korthuis · 2022 to 2026
$3.3M
Transporting treatment effects from clinical trials to real-world populations with co-occurring opioid and stimulant use disordersK01DA055130 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI COOK, RYAN · 2022 to 2025
$714k
NIDA NIH HHS K01 DA055130NIDA NIH HHS R01 DA057670NIDA NIH HHS UG1DA015815SAMHSA HHS CFDA 93.788 #H79TI085732
6 · The paper itself

Abstract

backgroundContingency management (CM) that is delivered by peer recovery support specialists and incentivizes harm reduction goals among people not seeking treatment for stimulant use has not been tested. The Peers Expanding Engagement in Stimulant Harm Reduction with Contingency Management (PEER-CM) study compares the effectiveness of two peer-facilitated CM interventions: (1) an experimental approach incentivizing achievement of client-identified harm reduction goals and (2) an enhanced standard of care approach incentivizing peer visit attendance.

methodsApplying a hybrid type 1 effectiveness-implementation framework and stepped-wedge design across 14 community-based peer services sites across Oregon, the PEER-CM study trains peers to conduct CM. All sites implement the standard CM approach of incentivizing peer visit attendance. Every 2 months, two sites are randomly assigned to initiate the experimental CM condition of incentives for achieving client-directed harm reduction activities. Peers monitor progress and manage incentives. In the experimental approach, peers facilitate client progress on goal-related activities (selected from a standardized list of goals) to support the primary study outcome of reducing opioid overdoses and stimulant overamping. The intended study enrollment is approximately 80 clients per site (N = 1,120). Peer specialists participate in skills-focused coaching-to-criterion coaching process to document proficient CM delivery skills. This includes a series of group coaching sessions and an individual assessment with a standardized patient, observed and rated according to core dimensions of the Contingency Management Competence Scale.

resultsThe primary study outcome is time until peer-reported fatal or first participant-reported non-fatal overdose or overamp (acute stimulant toxicity). Secondary outcomes include achievement of client-identified harm reduction goals and engagement in substance use disorder treatment. We will also demonstrate the feasibility of our coaching-to-criterion process by documenting peer proficiency in CM skills. Qualitative interviews with peers and their clients will explore the optimal context and implementation strategies for peer-facilitated CM.

conclusionPEER-CM is among the first trials to test the effectiveness of peer-facilitated CM for achieving harm reduction goals and reducing overdose in non-treatment-seeking people who use stimulants. The findings will generate evidence for peer-facilitated delivery of CM and application of CM to client-identified harm reduction goals.

trial registrationThis study is registered at ClinicalTrials.gov (NCT05700994).

Indexed as

Central Nervous System StimulantsHarm ReductionPeer GroupAdultFemaleHumansMaleMotivationOpiate OverdoseOregonCentral Nervous System StimulantsContingency managementImplementationPeer supportStimulant use

Identifiers

PMID40495203
PMCPMC12150483

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.