Evidence map›Paper›PMID 40495150›Full record

ArticleGenetics, selection, evolution : GSE2025

Whole-genome resequencing reveals positive selection and introgression signatures and genetic loci associated with early puberty traits in Chinese indigenous pigs.

Minghao Cao, Tiantian Yuan, Dong Li, Yulong Wang, Lin Zhang, Jingchun Sun, Guangquan Lv, Rongrong Ding, Taiyong Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, selection, evolution : GSE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minghao Cao *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Tiantian Yuan *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Dong Li *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Yulong WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Lin ZhangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Jingchun SunKey Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Guangquan LvKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Rongrong DingKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Taiyong YuKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. yutaiyong310@nwsuaf.edu.cn.

Funding

Biological Breeding-Major Projects in National Science and Technology 2023ZD04044Key Industry Innovation Chain of Shaanxi 2022GD-TSLD-46
6 · The paper itself

Abstract

backgroundThe genetic basis of the phenotypic diversity of pigs is regulated by variants across the genome, especially the trait of early puberty, which is a crucial trait for enhancing the reproductive ability of pigs and the economy of the pig industry. However, the genetic basis of the early puberty trait in pigs remains largely unknown.

resultsHere, we report a comprehensive genomic variation map for pigs based on the resequencing of 493 accessions representing 59 different pig breeds or populations, which included 5,211,469 single-nucleotide polymorphisms (SNPs) and 487,725 small insertion/deletion structure variants (InDels). This sets included 45,640 high-quality structural variants (SVs). Our results suggested that Hanjiang black (HJB) pigs cluster with Jianghai-type pigs at the genetic level and that the genome characteristics of some HJB individuals exhibit a certain degree of European pig features. Using introgression and signature selection analysis, we identified several candidate genes associated with bone development and early puberty traits, such as TBX5, PAPPA2, IGFBP3, and MKRN3. Additionally, the GWAS and differential expression analysis results suggested that the PAPPA2 gene is associated with early puberty in pigs.

conclusionsThis study revealed that past introgression events could impact the agronomical traits of pigs and contribute raw material of genetics and breeding in pig. Moreover, our results suggest that the PAPPA2 gene is a candidate gene associated with early sexual maturity in pigs and the genomic analysis provided important reference value for studying economic traits for pigs.

Indexed as

Quantitative Trait LociSelection, GeneticSexual MaturationAnimalsBreedingGenome-Wide Association StudyINDEL MutationPhenotypePolymorphism, Single NucleotideSwineWhole Genome Sequencing

Identifiers

PMID40495150
PMCPMC12150574

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.