Observational studyBMC cancer2025
Health-related quality of life is a significant prognostic factor for recurrence and overall survival in patients with colon cancer.
Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03910894 (Health-related Quality of Life in Colon Cancer Patients), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Health-related Quality of Life in Colon Cancer Patients
Who cites it
2 citing papers in PubMed.
- Global landscape and temporal trends in lifetime risk of colorectal cancer in 185 countries: a population-based study.Cancer biology & medicine · 2026Article
- Hope, strength, and survival: exploring positive psychology interventions in breast cancer care.Annals of medicine and surgery (2012) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealth-related quality of life (HRQoL) is associated with survival in patients with cancer; however, there are few studies on the risk of cancer recurrence. We investigated whether HRQoL can predict disease-free and overall survival (DFS/OS) in patients with non-metastatic colon cancer.
methodsThis population-based prospective study investigated patients diagnosed with colon cancer between 2012 and 2016. The 30-item European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) was used to measure HRQoL at diagnosis. Cox proportional hazard regression analyses were used to analyse the association between QLQ-C30 scores and DFS/OS.
resultsOf the 323 patients with non-metastatic colorectal cancer, n = 41 (12.7%) were diagnosed with recurrence during mean (standard deviation) DFS and OS follow-up times of 5.9 (2.9) and 6.2 (2.7) years, respectively. Cox regression analysis of HRQoL, adjusted for important clinical and demographic variables, showed that a higher global health status was significantly associated with an improved DFS (hazard ratio [HR] 0.86 per 10 points; 95% confidence interval [CI] 0.79-0.94; P < 0.001) as well as OS (HR 0.88 per 10 points; 99% CI 0.80-0.96; P = 0.003).
conclusionsThese results demonstrate that HRQoL can predict both DFS and OS in patients with non-metastatic colon cancer. HRQoL should be considered an additional tool in non-metastatic cancer for assessing patients at risk of metastatic disease.
trial registrationClinicalTrials.gov (NCT03910894).
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