ArticleLipids in health and disease2025
Concordant and discordant roles of remnant cholesterol and hs-CRP in cardiovascular disease; gender stratified analysis.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Beyond traditional risk factors: the impact of cumulative inflammation and remnant cholesterol on myocardial infarction in a prospective cohort study.Lipids in health and disease · 2026Article
- Long-Term Outcomes After Percutaneous Coronary Intervention According to the High-Sensitivity C-Reactive Protein-to-Albumin Ratio in Patients With Chronic Obstructive Pulmonary Disease in China.Reviews in cardiovascular medicine · 2026Article
- Triglyceride-Rich Lipoproteins and Inflammation: Independent and Synergistic Roles in Cardiovascular Disease.Current atherosclerosis reports · 2026Review
- C-reactive protein in cardiovascular disease: clinical associations, conformation-dependent biology, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Nonlinear association between remnant cholesterol inflammation index and incident stroke among middle-aged and older adults with hypertension: a CHARLS cohort study.Frontiers in cardiovascular medicine · 2026Article
- Emerging importance of remnant cholesterol compared with low-density lipoprotein cholesterol in cardiovascular risk assessment.Scientific reports · 2025Article
- Residual cholesterol inflammatory index and its prognostic role in mortality among individuals with cardiovascular-kidney-metabolic syndrome stages 0-3 based on U.S. and Chinese national cohorts.European journal of medical research · 2025Article
- Diagnostic efficacy of remnant cholesterol inflammatory index in diabetic kidney disease: machine learning approaches.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
introductionEvidence has found that high-sensitivity C-reactive protein (hs-CRP) can predict cardiovascular disease (CVD). Additionally, some research has suggested a combined effect of hs-CRP and remnant cholesterol (RC) in the development of CVD. Recognizing the significance of assessing both markers as predictive factors, this study aims to examine the association between RC and hs-CRP levels with the occurrence of CVD, coronary artery disease (CAD), and brain ischemic stroke in the Iranian population, categorized by gender. MATERIALS AND
methodsThe research involved 6985 participants from an Iranian cohort study. At the onset of the study, serum hs-CRP and RC levels were assessed. After ten years, occurrences of CVD, CAD, and brain ischemic events were evaluated. Furthermore, a survival and gender-stratified analysis was conducted to understand this association better.
resultsParticipants with high RC but low hs-CRP had a 23.5% and 24% increase in CVD and CAD risk, while those with both elevated RC and hs-CRP had a 44.9% and 57% higher risk for CVD and CAD. Among women, the combination of elevated RC and hs-CRP was linked to a 36.7% increase in CAD risk. Survival analysis supported these findings, showing that individuals with elevated RC and hs-CRP levels had the shortest survival times for CVD (134.55 months) and CAD (135.30 months).
conclusionThe combined use of RC and hs-CRP markers can strongly predict CVD and CAD, particularly in men. However, no association was found between RC and hs-CRP in brain ischemic stroke. To definitively address this issue, it is crucial to conduct future studies with a larger sample size that specifically target brain ischemic stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.