Evidence map›Paper›PMID 40495062›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

Umbilical analgesic concentrations after labour analgesia with programmed intermittent epidural bolus: a prospective observational study.

Arisa Ijuin, Masaki Sato, Nagayoshi Umehara, Shoichiro Amari, Jumpei Saito, Mayuko Abe, Wataru Matsunaga, Yoko Yamashita, Yasuyuki Suzuki, Kenichi Masui

Abstract readObservational Study
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In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arisa Ijuin *Division of Obstetric Anesthesiology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Masaki SatoDivision of Obstetric Anesthesiology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Nagayoshi UmeharaDivision of Obstetrics, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Shoichiro AmariDivision of Neonatology, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Jumpei SaitoDepartment of Pharmacy, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Mayuko AbeDivision of Obstetric Anesthesiology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Wataru MatsunagaDivision of Obstetric Anesthesiology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Yoko YamashitaDivision of Obstetric Anesthesiology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Yasuyuki SuzukiDivision of Obstetric Anesthesiology, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Kenichi Masui *Department of Anesthesiology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan. kenichi@masuinet.com.ORCID 0000-0003-4702-9874

Funding

Non-US Government Research Support
6 · The paper itself

Abstract

purposeThe umbilical analgesic concentrations after using programmed intermittent epidural bolus (PIEB) and patient-controlled epidural analgesia (PCEA) without continuous infusion are unknown. We aimed to characterize umbilical ropivacaine and fentanyl concentrations and examine their influence on neonatal conditions at delivery.

methodsWe prospectively studied 50 parturients with singleton pregnancies who received combined spinal-epidural analgesia using PIEB (7 mL every 45 min) and PCEA (7 mL per bolus; lockout interval: 15 min) with 0.08% ropivacaine and 2 μg·mL

resultsThe median [interquartile range (IQR)] hourly ropivacaine and fentanyl doses were 13 [11-15] mg·hr

conclusionsUmbilical analgesic concentrations at delivery were low after labour analgesia using a regimen of PIEB with PCEA for up to 19 hr. An intermittent bolus dosing regimen may contribute to a decrease in umbilical analgesic concentrations.

Indexed as

AmidesAnalgesia, EpiduralAnalgesia, ObstetricalAnesthetics, LocalFentanylFetal BloodAdultAnalgesia, Patient-ControlledAnalgesics, OpioidApgar ScoreFemaleHumansInfant, NewbornPregnancyProspective StudiesRopivacaineAmidesAnalgesics, OpioidAnesthetics, LocalFentanylRopivacainefentanyllabour analgesiaprogrammed intermittent epidural bolusropivacaine

Identifiers

PMID40495062

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.