SynthesisNeurosurgical review2025
Socioeconomic status as a determinant of survival in glioblastoma: a systematic review and meta-analysis.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Socioeconomic disparities in IDH-wildtype glioblastoma survival: interactions between age and household income in a SEER cohort.Journal of neuro-oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies highlight the importance of social factors, such as race and socioeconomic status (SES), in disease management. Integrating these factors helps improve understanding of disease outcomes and the development of effective treatments. Thus, we aimed to systematically identify and review relevant studies exploring the relationship between SES and survival outcomes in GBM patients. An extensive exploration of academic databases, including Scopus, EMBASE, and PubMed, was undertaken, covering records from their inception until December 14, 2024. This search targeted specific keywords and their synonymous terms: glioblastoma, survival, and socioeconomic. We included 230,601 patients, with many individuals being diagnosed between the ages of 46 and 65. Notably, Female exhibited a higher risk (HR = 1.07, 95% CI: 1.05-1.09) of death compared to male, while African Americans demonstrated a higher risk than Caucasians (HR = 0.92, 95% CI: 0.88-0.97), alongside Hispanics (HR = 0.85, 95% CI: 0.72-0.99) and other races (HR = 0.78, 95% CI: 0.73-0.85). Similarly, unmarried individuals faced a higher risk (HR = 1.14, 95% CI: 1.09-1.20) compared to married counterparts. Noteworthy trends were observed in insurance, where private payers (HR = 1.11, 95% CI: 1.06-1.15) and government-based insurance (HR = 1.09, 95% CI: 1.00-1.19) showed increased risks compared to private insurance. However, associations in widowhood (HR = 2.45, 95% CI: 0.34-17.40), comorbidities (HR = 1.05, 95% CI: 0.93-1.18), median household income (MHI) (HR = 0.94, 95% CI: 0.85-1.05), and rural living (HR = 1.06, 95% CI: 0.98-1.16) were non-significant or inconclusive. These findings emphasize the complex interplay between socioeconomic factors and health risks, highlighting the necessity for tailored interventions to address health disparities across diverse demographic groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.