Evidence map›Paper›PMID 40495034›Full record

ArticleEMBO reports2025

CD206+ macrophages facilitate wound healing through interactions with Gpnmb

Azusa Honda, Hiroyuki Koike, Teruyuki Dohi, Eri Toyohara, Sumio Hayakawa, Kazuyuki Tobe, Ichiro Manabe, Rei Ogawa, Yumiko Oishi

Abstract read
In one paragraph

Article in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Macrophage-Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Quantifying Information Exchange Between Cells in Inflammaging.Bioengineering (Basel, Switzerland) · 2026
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Azusa HondaDepartment of Biochemistry & Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
Hiroyuki KoikeDepartment of Biochemistry & Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.ORCID 0000-0001-9934-6930
Teruyuki DohiDepartment of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.ORCID 0000-0001-7316-8961
Eri ToyoharaDepartment of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
Sumio HayakawaDepartment of Biochemistry & Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
Kazuyuki TobeFirst Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama, 930-0194, Japan.
Ichiro ManabeDepartment of Systems Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.
Rei OgawaDepartment of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.ORCID 0000-0003-3658-555X
Yumiko OishiDepartment of Biochemistry & Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan. oishi.yumiko@tmd.ac.jp.ORCID 0000-0002-4761-0952

Funding

Japan Agency for Medical Research and Development (AMED) JP20gm6210023Japan Agency for Medical Research and Development (AMED) JP21bm0704045MEXT | Japan Science and Technology Agency (JST) JPMJFR2351MEXT | Japan Science and Technology Agency (JST) JPMJMS2023MEXT | Japan Society for the Promotion of Science (JSPS) 22K19534,23H02912MEXT | Japan Society for the Promotion of Science (JSPS) 23H02901,24K22112
6 · The paper itself

Abstract

Wound healing is a multifaceted and dynamic sequence of tissue repair and regeneration processes involving interrelated stages: inflammation, regeneration, and remodeling. Throughout these processes, macrophages change their phenotypes and interact with cells and extracellular components to facilitate healing. In particular, macrophages expressing the surface marker CD206 associate with inflammation resolution and tissue repair. However, how CD206

Indexed as

FibroblastsLectins, C-TypeMacrophagesMannose-Binding LectinsMembrane GlycoproteinsReceptors, Cell SurfaceScavenger Receptors, Class AWound HealingAnimalsCell CommunicationCell ProliferationEye ProteinsInflammationMannose ReceptorMiceMice, Inbred C57BLEye ProteinsGpnmb protein, mouseLectins, C-TypeMannose-Binding LectinsMannose ReceptorMembrane GlycoproteinsReceptors, Cell SurfaceScavenger Receptors, Class AHypertrophic ScarMacrophagesPDGFAWound Healing

Identifiers

PMID40495034
PMCPMC12287335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.