ArticleSurgery today2025
Clinical impact of bile culture from gallbladder in patients undergoing laparoscopic cholecystectomy for acute cholecystitis.
Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- An intraoperative bile culture does not improve the outcomes or guide antibiotic management in acute cholecystitis: A Propensity-Weighted analysis.Surgery today · 2026Article
- Surgical Treatment for Bacteremia due to Translocation ofSurgical case reports · 2026Article
- The Microbiological Spectrum and Antibiotic Resistance in Acute Acalculous and Calculous Cholecystitis: A Seven-Year Study in a Tertiary Center.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
12 authors.
Funding
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Abstract
purposeThis study investigated the trends in bacterial growth and antibiotic resistance patterns in gallbladder bile from patients with acute cholecystitis (AC) undergoing laparoscopic cholecystectomy and analyzed the risk factors for positive bile culture.
methodsWe conducted a retrospective cohort study of patients with AC who underwent emergency laparoscopic cholecystectomy between January 2012 and December 2024. Bile samples were collected directly from the gallbladder during surgery. Bile cultures and antibiotic susceptibility tests were performed, and risk factors for a positive bile culture were evaluated.
resultsAmong 243 patients, 145 (59.7%) were culture-positive. Patients with a positive culture were older (75.5 vs. 65.0 years old, p < 0.001) and had a significantly higher Tokyo Guidelines 2018 severity grade (p = 0.006) and longer hospital stay (p = 0.002) than those with a negative culture. In the multivariate analysis, we identified age ≥ 75 years old, preoperative endoscopic retrograde biliary drainage, and creatinine level ≥ 1 mg/dL as independent risk factors for a positive bile culture. The six most frequently identified microorganisms were Escherichia coli, Klebsiella, Enterococcus, Clostridium, Streptococcus, and Enterobacter.
conclusionThe use of appropriate empiric antibiotics in patients with risk factors for positive bile cultures may reduce the incidence of postoperative complications and the length of hospital stay.
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