ArticleCommunications medicine2025
The role of Life's Crucial 9 in cardiovascular disease incidence and dynamic transitions to dementia.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Longitudinal associations of cardiovascular-kidney-metabolic syndrome with midlife or late-life mental disorders and dementia, and the mediating role of metabolomic signature.Communications medicine · 2026Article
- Dementia and Heart Failure Classification Using Optimized Weighted Objective Distance and Blood Biomarker-Based Features.Bioengineering (Basel, Switzerland) · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundCardiovascular disease (CVD) often coexists with dementia as the contributor to disease burden in the aging population. Although the effects of several modifiable factors on the CVD and dementia risk have been increasingly recognized, their impacts on their dynamic transitions have not yet been explored. Therefore, we aimed to explore the role of Life's Crucial 9 (LC9; which includes measurements for diet, physical activity, smoking, BMI, cholesterol, blood pressure, blood sugar, sleep, and psychological health) in the dynamic transitions of CVD and dementia.
methodsUsing the UK Biobank (351,945 CVD-free participants, aged 40-70, and 55.1% female), we applied Cox proportional hazard model and the multi-state model to explore the relationships of LC9 with the dynamic transitions of CVD to dementia. We further examined which component of LC9 (behavior subscale, biological subscale, and psychological health) contributed to these dynamic transitions.
resultsOf the total CVD-free participants, we find that there are 35,316 newly onset CVD cases and 5426 dementia cases with a maximum follow-up of 16 years. Findings reveal that higher LC9 scores are associated with a lower risk of CVD, dementia, and dynamic transitions from CVD to dementia. Furthermore, these results suggest that psychological health contributes more strongly to dynamic transitions from CVD to dementia than the behavioral or biological subscales (Atrial fibrillation to dementia: hazard ratio [HR] = 1.48, 95% confidence interval [CI] = 1.20-1.81; Ischemic stroke to dementia: HR = 1.39, 95% CI = 1.02-1.89; Myocardial infarction to dementia: HR = 1.48, 95% CI = 1.03-2.13; Heart failure to dementia: HR = 1.59, 95% CI = 1.22-2.07).
conclusionsOur findings highlight the need for closer surveillance of psychological health in CVD patients to lower the risk of subsequent dementia incidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.