Evidence map›Paper›PMID 40494941›Full record

SynthesisInternational journal of clinical oncology2025

Systematic review and meta-analysis of photon radiotherapy versus proton beam therapy for pediatric rhabdomyosarcoma: TRP-rhabdomyosarcoma 2024.

Hiroko Fukushima, Masashi Mizumoto, Sho Hosaka, Yinuo Li, Kazushi Maruo, Yoshiko Oshiro, Hazuki Nitta, Takashi Iizumi, Takashi Saito, Masako Inaba and 4 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hiroko FukushimaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 305-8576, Japan.ORCID http://orcid.org/0000-0002-1290-3501
Masashi MizumotoDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan. mizumoto@pmrc.tsukuba.ac.jp.
Sho HosakaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 305-8576, Japan.
Yinuo LiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Kazushi MaruoDepartment of Biostatistics, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Yoshiko OshiroDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Hazuki NittaDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Takashi IizumiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Takashi SaitoDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Masako InabaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 305-8576, Japan.
Ryoko SuzukiDepartment of Child Health, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Kei NakaiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Shosei ShimizuProton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.
Hideyuki SakuraiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildhood cancer treatment has increasingly achieved favorable long-term survival rates, shifting focus toward reducing long-term comorbidities. Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue tumor, and radiation therapy is essential for its treatment. Proton beam therapy (PBT) is currently utilized due to its potential to reduce long-term complications; however, data on its impact on tumor prognosis remain limited.

methodsWe conducted a meta-analysis to evaluate whether differences in tumor prognosis exist based on radiation therapy modalities, such as photon radiotherapy (photon RT) and PBT, for pediatric parameningial RMS-only study (Group 2) and other pediatric RMS (Group 1). Studies published between 1990 and 2022 were included if they were written in English, included more than 10 cases, and reported outcomes such as overall survival (OS) and local control rates (LC).

resultsA total of 37 results (photon RT: 23, PBT: 14) were analyzed using random-effects meta-analyses. No significant differences were observed between treatment modalities in 1- to 5-year OS (photon RT vs. PBT) in Group 1. Early (1- and 3-year) inferior LC rates were observed with PBT in Group 2. DISCUSSION AND

conclusionOverall survival or LC rates don't differ significantly between cases treated with photon RT and those treated with PBT. The inferior early LC rates in cases of parameningeal-only RMS study treated with PBT may be attributed to the limited number of studies describing PBT, many of which were single-center reports. Unbiased clinical trial data are needed to clarify differences in early local relapses in parameningeal RMS.

Indexed as

PhotonsProton TherapyRhabdomyosarcomaChildHumansPrognosisMeta-analysisProton beam therapyRadiotherapy modalityRhabdomyosarcoma

Identifiers

PMID40494941
PMCPMC12296975

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.